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感知线粒体乙酰辅酶 A 以调节呼吸。

Sensing Mitochondrial Acetyl-CoA to Tune Respiration.

机构信息

Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA.

Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA; Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

出版信息

Trends Endocrinol Metab. 2019 Jan;30(1):1-3. doi: 10.1016/j.tem.2018.10.003. Epub 2018 Nov 12.

DOI:10.1016/j.tem.2018.10.003
PMID:30442533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6380363/
Abstract

Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al.[1] (Mol. Cell 2018;71:567-580) shows that mitochondrial FAS regulates the assembly of oxidative phosphorylation complexes, thereby functioning as a nutrient sensor for mitochondrial respiration.

摘要

线粒体中的脂肪酸合成（FAS）产生一种称为硫辛酸的关键代谢物。然而，Van Vranken 等人的一项新研究[1]（Mol. Cell 2018;71:567-580）表明，线粒体 FAS 调节氧化磷酸化复合物的组装，从而作为线粒体呼吸的营养传感器发挥作用。

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Acetyl-acyl carrier protein is not a major intermediate in fatty acid biosynthesis in spinach.乙酰酰基载体蛋白不是菠菜脂肪酸生物合成中的主要中间体。
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本文引用的文献

1
MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo.MITO-Tag 小鼠可实现从体内特定细胞类型中快速分离和多模式分析线粒体。
Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):303-312. doi: 10.1073/pnas.1816656115. Epub 2018 Dec 12.
2
ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly.ACP 酰化是电子传递链组装所必需的依赖乙酰辅酶 A 的修饰。
Mol Cell. 2018 Aug 16;71(4):567-580.e4. doi: 10.1016/j.molcel.2018.06.039.
3
Fatty acid synthesis configures the plasma membrane for inflammation in diabetes.脂肪酸合成会使糖尿病患者的质膜发生改变以适应炎症反应。
Nature. 2016 Nov 10;539(7628):294-298. doi: 10.1038/nature20117. Epub 2016 Nov 2.
4
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.线粒体脂肪酸合成、脂肪酸和线粒体生理学。
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jan;1862(1):39-48. doi: 10.1016/j.bbalip.2016.08.011. Epub 2016 Aug 21.
5
The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis.线粒体酰基载体蛋白（ACP）将线粒体脂肪酸合成与铁硫簇生物合成协调起来。
Elife. 2016 Aug 19;5:e17828. doi: 10.7554/eLife.17828.
6
Mitochondrial fatty acid synthesis and respiration.线粒体脂肪酸合成与呼吸作用。
Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1195-202. doi: 10.1016/j.bbabio.2010.03.006. Epub 2010 Mar 11.
7
Mitochondrial fatty acid synthesis type II: more than just fatty acids.II型线粒体脂肪酸合成：不止于脂肪酸。
J Biol Chem. 2009 Apr 3;284(14):9011-5. doi: 10.1074/jbc.R800068200. Epub 2008 Nov 21.
8
ACYL CARRIER PROTEIN. IV. THE IDENTIFICATION OF 4'-PHOSPHOPANTETHEINE AS THE PROSTHETIC GROUP OF THE ACYL CARRIER PROTEIN.酰基载体蛋白。IV. 鉴定4'-磷酸泛酰巯基乙胺为酰基载体蛋白的辅基。
Proc Natl Acad Sci U S A. 1965 Feb;53(2):410-7. doi: 10.1073/pnas.53.2.410.
9
Fatty acid synthase, a proficient multifunctional enzyme.脂肪酸合酶，一种高效的多功能酶。
Biochemistry. 1989 May 30;28(11):4523-30. doi: 10.1021/bi00437a001.