通过分子诊断选择尘螨过敏患者可能会提高特异性免疫治疗的成功率。 - Suppr

Selection of house dust mite-allergic patients by molecular diagnosis may enhance success of specific immunotherapy.

作者信息

Chen Kuan-Wei, Zieglmayer Petra, Zieglmayer René, Lemell Patrick, Horak Friedrich, Bunu Carmen Panaitescu, Valenta Rudolf, Vrtala Susanne

机构信息

Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; OncoGen Center, County Clinical Emergency Hospital "Pius Branzeu", Timisoara, Romania.

Vienna Challenge Chamber, Allergy Center Vienna West, Vienna, Austria.

出版信息

J Allergy Clin Immunol. 2019 Mar;143(3):1248-1252.e12. doi: 10.1016/j.jaci.2018.10.048. Epub 2018 Nov 14.

DOI:10.1016/j.jaci.2018.10.048

PMID:30445063

Abstract

摘要

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Selection of house dust mite-allergic patients by molecular diagnosis may enhance success of specific immunotherapy.通过分子诊断选择尘螨过敏患者可能会提高特异性免疫治疗的成功率。

J Allergy Clin Immunol. 2019 Mar;143(3):1248-1252.e12. doi: 10.1016/j.jaci.2018.10.048. Epub 2018 Nov 14.

Development of recombinant stable house dust mite allergen Der p 3 molecules for component-resolved diagnosis and specific immunotherapy.用于组分解析诊断和特异性免疫治疗的重组稳定屋尘螨变应原Der p 3分子的研发

Clin Exp Allergy. 2015 Apr;45(4):823-34. doi: 10.1111/cea.12452.

Cross-Reactivity between Major IgE Epitopes of Family 5 Allergens from Dermatophagoides pteronyssinus and Blomia tropicalis.来自尘螨和热带无爪螨的5类变应原主要IgE表位之间的交叉反应性。

Int Arch Allergy Immunol. 2019;178(1):10-18. doi: 10.1159/000492871. Epub 2018 Oct 31.

Patterns of IgE sensitization in house dust mite-allergic patients: implications for allergen immunotherapy.屋尘螨过敏患者的 IgE 致敏模式：变应原免疫治疗的意义。

Allergy. 2016 Feb;71(2):220-9. doi: 10.1111/all.12796. Epub 2015 Nov 13.

Der p 1 and Der p 2 specific immunoglobulin E measurement for diagnosis of allergy: A systematic review and meta-analysis.用于过敏诊断的特异性免疫球蛋白E检测：一项系统评价与Meta分析。

Allergy Asthma Proc. 2017 Sep 1;38(5):333-342. doi: 10.2500/aap.2017.38.4073.

Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy.基于 Der p1 的免疫毒素作为治疗尘螨呼吸过敏的潜在工具。

Sci Rep. 2020 Jul 23;10(1):12255. doi: 10.1038/s41598-020-69166-w.

IgE Abs to Der p 1 and Der p 2 as diagnostic markers of house dust mite allergy as defined by a bronchoprovocation test.作为通过支气管激发试验定义的屋尘螨过敏诊断标志物的针对Der p 1和Der p 2的IgE抗体。

Allergol Int. 2015 Jan;64(1):90-5. doi: 10.1016/j.alit.2014.08.004. Epub 2014 Oct 28.

Differences in Molecular Sensitization Profiles Between Spanish and Latin American Mite-Allergic Patients.西班牙和拉丁美洲螨虫过敏患者分子致敏谱的差异

J Investig Allergol Clin Immunol. 2025 Apr 22;35(2):114-121. doi: 10.18176/jiaci.0968. Epub 2024 Jan 4.

Serum and salivary IgE, IgA, and IgG4 antibodies to Dermatophagoides pteronyssinus and its major allergens, Der p1 and Der p2, in allergic and nonallergic children.过敏性和非过敏性儿童血清及唾液中针对屋尘螨及其主要过敏原Der p1和Der p2的IgE、IgA和IgG4抗体

Clin Dev Immunol. 2011;2011:302739. doi: 10.1155/2011/302739. Epub 2011 Oct 5.

Quality control of house dust mite extracts for allergen immunotherapy.用于变应原免疫疗法的屋尘螨提取物的质量控制

Int Arch Allergy Immunol. 2013;161(3):285-6. doi: 10.1159/000347045. Epub 2013 Mar 15.

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Characterization of the clinical relevance and hypoallergenic peptides of the newly evidenced major allergen Hum j 1.新证实的主要过敏原Hum j 1的临床相关性及低致敏性肽的特性分析

Front Immunol. 2025 Jun 23;16:1588870. doi: 10.3389/fimmu.2025.1588870. eCollection 2025.

Improved quality control of allergen products: Assessing the molecular allergen composition by mass spectrometry.改善变应原产品的质量控制：通过质谱法评估变应原的分子组成

Allergy. 2024 Dec;79(12):3489-3500. doi: 10.1111/all.16339. Epub 2024 Oct 24.

Optimization of Basophil Activation Test in the Diagnosis and Qualification for Allergen-Specific Immunotherapy in Children with Respiratory Allergy to the House Dust Mite .屋尘螨致儿童呼吸道变应性疾病变应原特异性免疫治疗中嗜碱性粒细胞活化试验的优化

Int J Mol Sci. 2024 Sep 15;25(18):9959. doi: 10.3390/ijms25189959.

Dermatophagoides pteronyssinus proteins and their role in the diagnostics and management of house dust mite allergy: exploring allergenic components.粉尘螨蛋白及其在屋尘螨过敏诊断和管理中的作用：探索致敏成分

Postepy Dermatol Alergol. 2024 Aug;41(4):339-349. doi: 10.5114/ada.2024.142390. Epub 2024 Aug 21.

Heterogenous Induction of Blocking Antibodies against Ragweed Allergen Molecules by Allergen Extract-Based Immunotherapy Vaccines.基于变应原提取物的免疫治疗疫苗对豚草变应原分子阻断抗体的异质性诱导

Vaccines (Basel). 2024 Jun 7;12(6):635. doi: 10.3390/vaccines12060635.

Advocacy of Precision Allergy Molecular Diagnosis in Decision Making for the Eligibility of Customized Allergen Immunotherapy.在定制过敏原免疫疗法适用性决策中倡导精准过敏分子诊断

Curr Issues Mol Biol. 2023 Dec 12;45(12):9976-9984. doi: 10.3390/cimb45120623.

House dust mite allergy in Malaysia: review of research gaps in the current scenario and the way forward.马来西亚的屋尘螨过敏：当前研究空白的综述及未来发展方向。

Exp Appl Acarol. 2023 Dec;91(4):509-539. doi: 10.1007/s10493-023-00857-5. Epub 2023 Nov 23.

Serological analysis of allergic components of house dust mite provides more insight in epidemiological characteristics and clinical symptom development in North China.血清学分析屋尘螨过敏原可更深入了解华北地区的流行病学特征和临床症状发展。

Front Immunol. 2023 Apr 27;14:1083755. doi: 10.3389/fimmu.2023.1083755. eCollection 2023.

Allergic March in Children: The Significance of Precision Allergy Molecular Diagnosis (PAMD@) in Predicting Atopy Development and Planning Allergen-Specific Immunotherapy.儿童过敏三月：精准过敏分子诊断（PAMD@）在预测特应性发展和规划变应原特异性免疫治疗中的意义。

Nutrients. 2023 Feb 15;15(4):978. doi: 10.3390/nu15040978.

Relationship between IgE Levels Specific for Ragweed Pollen Extract, Amb a 1 and Cross-Reactive Allergen Molecules.豚草花粉提取物、Amb a 1 特异性 IgE 水平与交叉反应性过敏原分子的关系。

Int J Mol Sci. 2023 Feb 17;24(4):4040. doi: 10.3390/ijms24044040.

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Selection of house dust mite-allergic patients by molecular diagnosis may enhance success of specific immunotherapy.

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