Outpatient Allergology Clinic, The Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland.
Department of Health Promotion, Chair of Nursing Development, Faculty Health of Sciences, Medical University of Lublin, Staszica 4/6, 20-081 Lublin, Poland.
Nutrients. 2023 Feb 15;15(4):978. doi: 10.3390/nu15040978.
The allergic march is a progression of naturally occurring symptoms whose nature changes with age. The classic allergic march typically begins in infancy and manifests in the form of atopic dermatitis and food allergy. As immune tolerance develops over time, these conditions may resolve by the age of 3-5 years; however, they may evolve into allergic rhinitis and bronchial asthma. Traditional diagnostic assessments, such as skin prick testing or serum allergen-specific immunoglobulin E (sIgE) level testing, are conducted to introduce effective treatment. Recent years saw the emergence of precision allergy molecular diagnosis (PAMD@), which assesses sIgE against allergenic molecules. This new technology helps more accurately evaluate the patient's allergy profile, which helps create more precise dietary specifications and personalize allergen-specific immunotherapy. This review presents possible predictions regarding the allergic march and the means of controlling it based on PAMD@ results.
过敏进程是一系列自然发生的症状，其性质随年龄而变化。典型的过敏进程通常始于婴儿期，表现为特应性皮炎和食物过敏。随着时间的推移，免疫耐受逐渐发展，这些疾病可能在 3-5 岁时得到缓解；然而，它们可能会发展成过敏性鼻炎和支气管哮喘。传统的诊断评估，如皮肤点刺试验或血清过敏原特异性免疫球蛋白 E（sIgE）水平检测，用于引入有效的治疗方法。近年来出现了精准过敏分子诊断（PAMD@），它评估针对过敏原分子的 sIgE。这项新技术有助于更准确地评估患者的过敏情况，从而制定更精确的饮食规范并实现过敏原特异性免疫治疗的个体化。本综述根据 PAMD@结果，对过敏进程及其控制方法提出了一些可能的预测。
