Yen Hsu-Heng, Weng Meng-Tzu, Tung Chien-Chih, Wang Yu-Ting, Chang Yuan Ting, Chang Chin-Hao, Shieh Ming-Jium, Wong Jau-Min, Wei Shu-Chen
Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Department of Endoscopy Center, Changhua Christian Hospital, Changhua, Taiwan.
Intest Res. 2019 Jan;17(1):54-62. doi: 10.5217/ir.2018.00096. Epub 2018 Nov 20.
BACKGROUND/AIMS: Incidences of inflammatory bowel diseases (IBDs), ulcerative colitis (UC), and Crohn's disease (CD), have been increasing in Asia. In this study, we report the relevant clinical characteristics and determined the epidemiological trend of IBD in Taiwan from 2001 to 2015.
A retrospective study was conducted to analyze data recorded from January 2001 through December 2015 in the registered database compiled by the National Health Insurance and provided by the Ministry of Health and Welfare, Taiwan.
A total of 3,806 patients with catastrophic IBD illness were registered from 2001 to 2015 in Taiwan (CD, 919; UC, 2,887). The crude incidence of CD increased from 0.17/100,000 in 2001 to 0.47/100,000 in 2015, whereas that of UC increased from 0.54/100,000 in 2001 to 0.95/100,000 in 2015. The prevalence of CD increased from 0.6/100,000 in 2001 to 3.9/100,000 in 2015, whereas that of UC increased from 2.1/100,000 in 2001 to 12.8/100,000 in 2015. The male-to-female ratio in the study sample was 2.19 for CD and 1.62 for UC. The median age of those registered with CD was lower than that of those registered for UC: 38.86 and 44.86 years, respectively. A significantly greater increase in CD incidence rate was identified among 20 to 39-year-old compared with other age groups.
Using Taiwan's nationwide insurance database, we determined that the number of patients with CD increased more rapidly during the study period than the number of patients with UC, especially among age 20 to 39-year-old, resulting in a decreased UC-to-CD ratio.
背景/目的：亚洲地区炎症性肠病（IBD）、溃疡性结肠炎（UC）和克罗恩病（CD）的发病率一直在上升。在本研究中，我们报告了相关临床特征，并确定了2001年至2015年台湾地区IBD的流行病学趋势。
进行了一项回顾性研究，以分析2001年1月至2015年12月期间台湾地区卫生福利部提供的国民健康保险登记数据库中记录的数据。
2001年至2015年期间，台湾地区共登记了3806例IBD重症患者（CD患者919例，UC患者2887例）。CD的粗发病率从2001年的0.17/10万增至2015年的0.47/10万，而UC的粗发病率则从2001年的0.54/10万增至2015年的0.95/10万。CD的患病率从2001年的0.6/10万增至2015年的3.9/10万，而UC的患病率则从2001年的2.1/10万增至2015年的12.8/10万。研究样本中，CD的男女比例为2.19，UC为1.62。CD登记患者的中位年龄低于UC登记患者，分别为38.86岁和44.86岁。与其他年龄组相比，20至39岁年龄组的CD发病率显著增加。
通过台湾地区的全国保险数据库，我们确定在研究期间CD患者数量的增长速度比UC患者更快，尤其是在20至39岁年龄组中，导致UC与CD的比例下降。
