外用维甲酸治疗衰老皮肤。
Topical tretinoin in the treatment of aging skin.
作者信息
Weiss J S, Ellis C N, Headington J T, Voorhees J J
机构信息
Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109-0314.
出版信息
J Am Acad Dermatol. 1988 Jul;19(1 Pt 2):169-75. doi: 10.1016/s0190-9622(88)70161-9.
We review the use of topical tretinoin (all-trans-retinoic acid) in the treatment of aging skin. We have found topical tretinoin capable of improving aged-appearing skin in both a double-blind, vehicle-controlled trial and our clinic patients. The most impressive improvement occurs after application of tretinoin 0.1% cream for 8 to 12 months. Side effects have been limited to a mild, transient, and clinically insignificant burning sensation in the eyes and mild irritation of tretinoin-exposed skin.
我们回顾了外用维甲酸（全反式维甲酸）在治疗皮肤老化方面的应用。我们发现在一项双盲、赋形剂对照试验以及我们诊所的患者中，外用维甲酸能够改善呈现老化迹象的皮肤。使用0.1%维甲酸乳膏8至12个月后出现的改善最为显著。副作用仅限于眼部出现轻微、短暂且临床意义不大的烧灼感，以及维甲酸接触部位皮肤出现轻度刺激。
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