Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou, China.
Department of Healthcare, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou, China.
JPEN J Parenter Enteral Nutr. 2019 Aug;43(6):803-808. doi: 10.1002/jpen.1472. Epub 2018 Nov 19.
Cow's milk protein allergy (CMPA) is commonly seen in children. There have been no reports of the true prevalence of CMPA in Chinese infants. The aim of this population-based study is to determine the prevalence, clinical characteristics, and outcome of CMPA in Chinese infants.
We carried out a prospective survey in 7 participating hospitals throughout southern China. We included infants ≤12 months of age during the survey. For those suspected of CMPA, oral food challenge with cow's milk protein (CMP) was performed. A follow-up telephone interview was conducted at 12 months after the diagnosis to assess the clinical outcome of CMPA.
A total of 9910 questionnaire surveys were distributed and 7364 (74.3%) were returned. The eligible survey number of surveys was 6768 (91.9%). A total of 182 infants was confirmed with CMPA, including 13 with anaphylactic reactions, 28 with clinical symptoms and serum immunoglobulin E (sIgE) >3.5 IU/mL, and 141 with positive CMP challenge test. The prevalence of CMPA was 2.69%. Infants with confirmed CMPA had significantly stronger family history of either 1 or both parents with food allergy, higher Cesarean section rate, and lower rate of breastfeeding, compared with those without CMPA. At 12-month telephone follow-up of 176 CMPA infants, 136 infants (77.3%) had become tolerant to CMP.
The prevalence of CMPA was 2.69%. CMPA infants had a strong family history of food allergy and atopy. Both Cesarean delivery and formula feeding were risk factors for CMPA. At 12-month follow-up, the majority of CMPA infants had become tolerant to CMP.
牛奶蛋白过敏（CMPA）在儿童中较为常见。目前尚无中国婴儿 CMPA 真实患病率的报道。本基于人群的研究旨在确定中国婴儿 CMPA 的患病率、临床特征和结局。
我们在华南地区的 7 家参与医院进行了一项前瞻性调查。我们纳入了调查期间≤12 个月的婴儿。对于疑似 CMPA 的婴儿，进行了牛奶蛋白（CMP）口服食物激发试验。在诊断后 12 个月进行了电话随访，以评估 CMPA 的临床结局。
共发放了 9910 份问卷，回收了 7364 份（74.3%）。合格调查数量为 6768 份（91.9%）。共确诊 182 例 CMPA 婴儿，其中 13 例为过敏反应，28 例为有临床症状和血清免疫球蛋白 E（sIgE）>3.5 IU/ml，141 例为 CMP 激发试验阳性。CMPA 的患病率为 2.69%。与无 CMPA 的婴儿相比，确诊为 CMPA 的婴儿的父母双方或一方有食物过敏史的家族史明显更强，剖宫产率更高，母乳喂养率更低。在对 176 例 CMPA 婴儿的 12 个月电话随访中，136 例（77.3%）对 CMP 已耐受。
CMPA 的患病率为 2.69%。CMPA 婴儿有食物过敏和特应性的强烈家族史。剖宫产和配方奶喂养均为 CMPA 的危险因素。在 12 个月的随访中，大多数 CMPA 婴儿已对 CMP 耐受。
