Chen Sheng-Huang, Yu Juan, Lia Qin-Wen, Zhao Jian-Ping, Wedge David E, Duke Stephen O, Liao Duan-Fang, Wang Yu-Hong, Fronczek Frank R, Khan Ikhlas A, Wanga Wei
Nat Prod Commun. 2016 Jul;11(7):931-934.
Phytochemical investigation of the roots and rhizomes of Pileostegia viburnoides var. glabrescens led to the isolation and identification of 31 compounds (1-31), 25 of which (1-2, 4-7, 9-12, 15-18, 21-31) were isolated from the Pileostegia genus for the first time. 7α-Hydroxyfriedelan-3-one-26-ol-29-oic acid (1) is a new friedelane-type triterpene. The structure of n-butyl-β-D-fructopyranoside (2) was determined by single-crystal X-ray diffraction. Compounds 4 and 12 displayed marginal cytotoxicity against the P388 murine leukemia cell line with IC₅₀ values of 13.4 μM and 25.0 μM, respectively. Compound 23 exhibited marginal anti-inflammatory activity by the inhibition of lipopolysaccharide induced nitric oxide production in RAW 264.7 macrophage cells, with an IC₅₀ value of 32.0 μM. Compounds 3, 8-10, 25, and 27 were phytotoxic to the dicot Lactuca sativa (lettuce) and/or the monocot Agrostis stolonifera (bentgrass).
对光叶冠盖藤根和根茎的植物化学研究导致分离并鉴定出31种化合物（1 - 31），其中25种（1 - 2、4 - 7、9 - 12、15 - 18、21 - 31）是首次从冠盖藤属植物中分离得到。7α - 羟基木栓烷 - 3 - 酮 - 26 - 醇 - 29 - 酸（1）是一种新的木栓烷型三萜。正丁基 - β - D - 果糖苷（2）的结构通过单晶X射线衍射确定。化合物4和12对P388小鼠白血病细胞系显示出微弱的细胞毒性，IC₅₀值分别为13.4 μM和25.0 μM。化合物23通过抑制脂多糖诱导的RAW 264.7巨噬细胞中一氧化氮的产生表现出微弱的抗炎活性，IC₅₀值为32.0 μM。化合物3、8 - 10、25和27对双子叶植物莴苣和/或单子叶植物匍匐翦股颖具有植物毒性。
