University of KwaZulu-Natal College of Health Sciences, Optometry.
Karolinska Institute, Clinical Neuroscience.
Afr Health Sci. 2023 Mar;23(1):137-148. doi: 10.4314/ahs.v23i1.16.
The present study investigated the integrity of contrast sensitivity (CS), colour vision, and pattern evoked vision potentials (VEP) in non-immunocompromised people living with HIV (NIPLHIV) without retinitis.
All participants were visually asymptomatic and no history of ocular disorders, with CD4 counts above 350 cells/mm, low viral loads and on ART. Thirty NIPLHIV and 30 age-matched HIV negative control groups underwent F100 hue colour assessment, Pelli-Robson contrast sensitivity assessment and pattern-reversal VEP.
The median F100 total error scores for NIPLHIV and controls was 33 (IQR: 28;41) and 28 (IQR: 26;48.50) respectively, this was statistically different (p= 0.020). The median P100 amplitude for NIPLHIV was 5.75 µV (IQR: 4.4;8.85) and 4.05 µV (IQR: 3.2;5.8) for controls, this was statistically different (p=0.045). The mean LogCS score 1.83±0.14 and the median P100 peak latency was 105.45 msec (IQR: 102.98;108.98) for NIPLHIV. Higher CD4+ counts were significantly associated with having higher F100 total error scores (OR=0.995; p=0.018), lower P100 amplitudes (OR=1.007; p=0.010) and higher P100 latencies (OR=0.994; p=0.011).
Contrast sensitivity function, colour vision, and VEP were uncompromised in NIPLHIV. Associations between CD4 counts with F100 total error scores and P100 latency may aid in the surveillance of vision of NIPLHIV.
本研究旨在调查非免疫抑制性人类免疫缺陷病毒（HIV）感染者（NIPLHIV）中无视网膜病变者的对比敏感度（CS）、色觉和图形视觉诱发电位（VEP）的完整性。
所有参与者均无视觉症状且无眼部疾病史，CD4 计数高于 350 个细胞/mm³，病毒载量低且正在接受抗逆转录病毒治疗（ART）。30 名 NIPLHIV 和 30 名年龄匹配的 HIV 阴性对照组接受 F100 色调色觉评估、Pelli-Robson 对比敏感度评估和图形翻转 VEP。
NIPLHIV 和对照组的 F100 总误差中位数分别为 33（IQR：28；41）和 28（IQR：26；48.50），差异有统计学意义（p=0.020）。NIPLHIV 的 P100 振幅中位数为 5.75µV（IQR：4.4；8.85），对照组为 4.05µV（IQR：3.2；5.8），差异有统计学意义（p=0.045）。NIPLHIV 的平均 LogCS 评分为 1.83±0.14，P100 峰潜伏期中位数为 105.45 毫秒（IQR：102.98；108.98）。较高的 CD4+计数与 F100 总误差评分较高（OR=0.995；p=0.018）、P100 振幅较低（OR=1.007；p=0.010）和 P100 潜伏期较高（OR=0.994；p=0.011）显著相关。
NIPLHIV 的对比敏感度功能、色觉和 VEP 均未受损。CD4 计数与 F100 总误差评分和 P100 潜伏期之间的相关性可能有助于监测 NIPLHIV 的视力。
