理解 PTSD 的基因组学更新。
Genomic updates in understanding PTSD.
机构信息
Neuroscience Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States; McLean Hospital, Division of Depression and Anxiety, Belmont, MA, United States.
McLean Hospital, Division of Depression and Anxiety, Belmont, MA, United States; Harvard Medical School, Boston, MA, United States; Neuroscience Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 2;90:197-203. doi: 10.1016/j.pnpbp.2018.11.010. Epub 2018 Nov 16.
Abstract
Twin studies as well as more recent genetics-based heritability analyses demonstrate that up to 40 to 50% of the variance in predicting PTSD following trauma is heritable. However, most of the specific gene pathways and mechanism that mediate risk vs. resilience for PTSD following trauma exposure have yet to be elucidated. This review will examine the latest results from large scale Genome-wide association studies as well as other approaches aimed at understanding mechanisms of development of and recovery from PTSD.
摘要
双生子研究以及最近基于遗传学的遗传率分析表明，创伤后预测 PTSD 的方差中有高达 40%至 50%是可遗传的。然而，大多数特定的基因途径和机制，用于介导创伤后 PTSD 的风险与韧性，尚未被阐明。这篇综述将检查大规模全基因组关联研究以及其他旨在了解 PTSD 发展和恢复机制的方法的最新结果。
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