Rodriguez Alexandra L, Whitehurst Michael, Fico Brandon G, Dodge Katelyn M, Ferrandi Peter J, Pena Gabriel, Adelman Avraham, Huang Chun-Jung
Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA.
Department of Kinesiology and Health Education, University of Texas, Austin, TX 78712, USA.
Exp Biol Med (Maywood). 2018 Oct;243(14):1153-1160. doi: 10.1177/1535370218812191. Epub 2018 Nov 19.
Obesity may attenuate the expression of brain-derived neurotrophic factor (BDNF), thereby increasing the risk of cognitive dysfunction. High-intensity interval exercise (HIIE) has been shown to be as or more effective than continuous moderate-intensity exercise (CME) in promoting the expression of BDNF in normal-weight individuals. Therefore, the primary purpose of this study was to examine whether or not acute HIIE could be utilized as a practical model to explore the BDNF response in obese versus normal-weight subjects when compared to acute CME. The potential relationship of exercise-induced BDNF with blood lactate and cortisol was also examined. Twelve male subjects (six obese and six normal-weight) participated in a counterbalanced and caloric equated experiment: HIIE (30 min, 4 intervals of 4 min at 80%–90% of VO with 3 min of active recovery at 50–60% VO) and CME (38 min at 50%–60% VO). Blood samples were collected prior to, immediately following exercise, and 1 h into recovery for measurements of serum BDNF, blood lactate, and plasma cortisol. Our results showed that the BDNF response to acute HIIE was greater than CME in obese subjects when compared to normal-weight subjects. Similarly, although acute HIIE induced greater blood lactate and plasma cortisol levels than CME, obese subjects produced less blood lactate, but no difference in cortisol than normal-weight subjects. These findings suggest that acute HIIE may be a more effective protocol to upregulate BDNF expression in an obese population, independent of increased lactate and cortisol levels.
High-intensity interval exercise (HIIE) has been shown to be a time-efficient exercise strategy that provides similar or superior physiological benefits as traditional continuous moderate-intensity exercise (CME). Our previous study demonstrated an equivalent elevation on the BDNF response in both obese and normal-weight individuals following 30 min of acute CME. To discover a time-efficient exercise strategy to improve brain health in an obese population, the present study found that obese individuals elicit a greater level of BDNF following acute HIIE versus CME than normal-weight individuals. These findings indicate that acute HIIE may be an effective strategy to upregulate BDNF expression in obese individuals.
肥胖可能会减弱脑源性神经营养因子（BDNF）的表达，从而增加认知功能障碍的风险。高强度间歇运动（HIIE）在促进正常体重个体的BDNF表达方面已被证明与持续中等强度运动（CME）效果相当或更有效。因此，本研究的主要目的是检验与急性CME相比，急性HIIE是否可以作为一种实用模型来探究肥胖与正常体重受试者的BDNF反应。还研究了运动诱导的BDNF与血乳酸和皮质醇之间的潜在关系。12名男性受试者（6名肥胖者和6名正常体重者）参与了一项平衡且热量相等的实验：HIIE（30分钟，4个4分钟的间歇，强度为最大摄氧量的80% - 90%，中间有3分钟50% - 60%最大摄氧量的主动恢复）和CME（38分钟，强度为最大摄氧量的50% - 60%）。在运动前、运动后即刻以及恢复1小时后采集血样，用于检测血清BDNF、血乳酸和血浆皮质醇。我们的结果表明，与正常体重受试者相比，肥胖受试者对急性HIIE的BDNF反应大于CME。同样，尽管急性HIIE比CME诱导出更高的血乳酸和血浆皮质醇水平，但肥胖受试者产生的血乳酸较少，而皮质醇水平与正常体重受试者无差异。这些发现表明，急性HIIE可能是一种更有效的方案，可在肥胖人群中上调BDNF表达，且与血乳酸和皮质醇水平升高无关。
高强度间歇运动（HIIE）已被证明是一种省时的运动策略，能提供与传统持续中等强度运动（CME）相似或更优的生理益处。我们之前的研究表明，急性CME 30分钟后，肥胖和正常体重个体的BDNF反应升高程度相当。为了找到一种省时的运动策略来改善肥胖人群的脑健康，本研究发现，与CME相比，肥胖个体在急性HIIE后的BDNF水平高于正常体重个体。这些发现表明，急性HIIE可能是上调肥胖个体BDNF表达的有效策略。
