关于野生型与肌营养不良症小鼠模型的小鼠唾液和血清的比较蛋白质组学分析数据集。
Dataset on the comparative proteomic profiling of mouse saliva and serum from wild type versus the dystrophic mouse model of dystrophinopathy.
作者信息
Murphy Sandra, Zweyer Margit, Mundegar Rustam R, Swandulla Dieter, Ohlendieck Kay
机构信息
Department of Biology, Maynooth University, National University of Ireland, Maynooth, Co. Kildare, Ireland.
Institute of Physiology II, University of Bonn, D‑53115 Bonn, Germany.
出版信息
Data Brief. 2018 Oct 27;21:1236-1245. doi: 10.1016/j.dib.2018.10.082. eCollection 2018 Dec.
The comparative proteomic data presented in this article provide supporting information to the related research article "Proteomic identification of elevated saliva kallikrein levels in the mouse model of Duchenne muscular dystrophy " (Murphy et al., 2018). Here we provide additional datasets on the comparative proteomic analysis of saliva and serum proteins and the mass spectrometric identification of kallikrein isoform Klk-1 in wild type versus saliva specimens. The data article presents the systematic identification of the assessable saliva proteome and the differential presence of proteins in saliva versus serum samples. Representative mass spectrometric scans of unique peptides that were employed to identify the kallikrein isoform Klk-1 in wild type versus saliva specimens are provided. The dataset contains typical saliva-associated marker proteins, including alpha-amylase and albumin, as well as distinct isoforms of cystatin, serpin, kallikrein, cathepsin, glutathione transferase, carbonic anhydrase, mucin, pyruvate kinase, and aldolase.
本文中呈现的比较蛋白质组学数据为相关研究文章《杜兴氏肌肉营养不良小鼠模型中唾液激肽释放酶水平升高的蛋白质组学鉴定》（墨菲等人，2018年）提供了支持信息。在此，我们提供了关于唾液和血清蛋白质比较蛋白质组学分析以及野生型与唾液标本中激肽释放酶同工型Klk-1的质谱鉴定的额外数据集。该数据文章展示了可评估唾液蛋白质组的系统鉴定以及唾液与血清样本中蛋白质的差异存在情况。提供了用于鉴定野生型与唾液标本中激肽释放酶同工型Klk-1的独特肽段的代表性质谱扫描图。该数据集包含典型的唾液相关标记蛋白，包括α-淀粉酶和白蛋白，以及胱抑素、丝氨酸蛋白酶抑制剂、激肽释放酶、组织蛋白酶、谷胱甘肽转移酶、碳酸酐酶、粘蛋白、丙酮酸激酶和醛缩酶的不同同工型。
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