Adey W R
VA Medical Center, Loma Linda, California 92357.
Neurochem Res. 1988 Jul;13(7):671-7. doi: 10.1007/BF00973286.
Use of weak electromagnetic fields to study the sequence and energetics of events that couple humoral stimuli from surface receptor sites to the cell interior has identified cell membranes as a primary site of interaction with these low frequency fields. Field modulation of cell surface chemical events indicates a major amplification of initial weak triggers associated with binding of hormones, antibodies and neurotransmitters to their specific binding sites. Calcium ions play a key role in this stimulus amplification, probably through highly cooperative alterations in binding to surface glycoproteins, with spreading waves of altered calcium binding across the membrane surface. Protein particles spanning the cell membrane form pathways for signaling and energy transfer. Fields millions of times weaker than the membrane potential gradient of 10(5) V/cm modulate cell responses to surface stimulating molecules. The evidence supports nonlinear, nonequilibrium processes at critical steps in transmembrane signal coupling. Powerful cancer-promoting phorbol esters act at cell membranes to stimulate ornithine decarboxylase which is essential for cell growth and DNA synthesis. This response is enhanced by weak microwave fields, also acting at cell membranes.
利用弱电磁场来研究将来自表面受体位点的体液刺激与细胞内部相耦合的事件序列和能量学，已确定细胞膜是与这些低频场相互作用的主要位点。细胞表面化学事件的场调制表明，与激素、抗体和神经递质与其特定结合位点结合相关的初始弱触发信号有显著放大。钙离子在这种刺激放大过程中起关键作用，可能是通过与表面糖蛋白结合的高度协同变化，以及跨膜表面钙结合改变的传播波来实现的。跨越细胞膜的蛋白质颗粒形成了信号传导和能量转移的途径。比10(5) V/cm的膜电位梯度弱数百万倍的场可调节细胞对表面刺激分子的反应。证据支持跨膜信号耦合关键步骤中的非线性、非平衡过程。强大的促癌佛波酯作用于细胞膜以刺激鸟氨酸脱羧酶，该酶对细胞生长和DNA合成至关重要。这种反应会被同样作用于细胞膜的弱微波场增强。
