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环境非电离电磁场与化学污染在癌症促进中的联合作用。

Joint actions of environmental nonionizing electromagnetic fields and chemical pollution in cancer promotion.

作者信息

Adey W R

机构信息

Research Service (151), Pettis Memorial VA Medical Center, Loma Linda, CA 92357.

出版信息

Environ Health Perspect. 1990 Jun;86:297-305. doi: 10.1289/ehp.9086297.

DOI:10.1289/ehp.9086297
PMID:2205491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1567752/
Abstract

Studies of environmental electromagnetic (EM) field interactions in tissues have contributed to a new understanding of both normal growth and the biology of cancer in cell growth. From cancer research comes a floodtide of new knowledge about the disruption of communication by cancer-promoting chemicals with an onset of unregulated growth. Bioelectromagnetic research reveals clear evidence of joint actions at cell membranes of chemical cancer promoters and environmental electromagnetic fields. The union of these two disciplines has resulted in the first major new approach to tumor formation in 75 years, directing attention to dysfunctions in inward and outward streams of signals at cell membranes, rather than to damage DNA in cell nuclei, and to synergic actions of chemical pollutants and environmental electromagnetic fields. We are witnesses and, in great measure, participants in one of the great revolutions in the history of biology. In little more than a century, we have moved from organs, to tissues, to cells, and finally to the molecules that are the elegant fabric of living tissues. Today, we stand at a new frontier. It may be more difficult to comprehend, but it is far more significant; for it is at the atomic level, rather than the molecular, that physical, rather than chemical, processes appear to shape the flow of signals that are at the essence of living matter. To pursue these problems in the environment and in the laboratory, our needs for further research with appropriate budgets are great.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

对组织中环境电磁场相互作用的研究,有助于人们对细胞生长中的正常发育以及癌症生物学产生新的认识。癌症研究带来了大量新知识,这些知识涉及促癌化学物质对通信的干扰以及由此引发的生长失控。生物电磁学研究清楚地证明了化学促癌剂与环境电磁场在细胞膜上的联合作用。这两个学科的结合,带来了75年来肿瘤形成研究的首个重大新方法,将关注点转向细胞膜内外信号流的功能障碍,而非细胞核中的DNA损伤,以及化学污染物与环境电磁场的协同作用。我们见证了,并且在很大程度上参与了生物学史上的一次重大革命。在短短一个多世纪里,我们从器官研究,发展到组织研究,再到细胞研究,最终深入到构成生命组织精美结构的分子层面。如今,我们站在了一个新的前沿。它可能更难理解,但却意义重大得多;因为在原子层面,而非分子层面,物理过程而非化学过程似乎塑造了作为生命物质本质的信号流动。为了在环境和实验室中研究这些问题,我们迫切需要有适当预算用于进一步研究。(摘要截选至250字)

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本文引用的文献

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Effects of ELF fields on calcium-ion efflux from brain tissue in vitro.极低频电磁场对体外脑组织钙离子外流的影响。
Radiat Res. 1982 Dec;92(3):510-20.
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Low frequency amplitude modulated microwave fields change calcium efflux rates from synaptosomes.低频调幅微波场改变突触体的钙外流速率。
Bioelectromagnetics. 1982;3(3):309-22. doi: 10.1002/bem.2250030303.
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3H-noradrenaline release potentiated in a clonal nerve cell line by low-intensity pulsed magnetic fields.低强度脉冲磁场增强克隆神经细胞系中3H-去甲肾上腺素的释放
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Effects of weak amplitude-modulated microwave fields on calcium efflux from awake cat cerebral cortex.弱调幅微波场对清醒猫大脑皮层钙外流的影响。
Bioelectromagnetics. 1982;3(3):295-307. doi: 10.1002/bem.2250030302.
6
Microwave radiation-induced calcium ion efflux from human neuroblastoma cells in culture.微波辐射诱导培养的人神经母细胞瘤细胞中钙离子外流。
Bioelectromagnetics. 1984;5(1):71-8. doi: 10.1002/bem.2250050108.
7
Suppression of T-lymphocyte cytotoxicity following exposure to sinusoidally amplitude-modulated fields.暴露于正弦波调幅场后T淋巴细胞细胞毒性的抑制
Bioelectromagnetics. 1983;4(3):281-92. doi: 10.1002/bem.2250040308.
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Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.蛋白激酶C作为促肿瘤佛波酯的一种可能的受体蛋白。
J Biol Chem. 1983 Oct 10;258(19):11442-5.
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Effects of electromagnetic stimuli on bone and bone cells in vitro: inhibition of responses to parathyroid hormone by low-energy low-frequency fields.体外电磁刺激对骨骼及骨细胞的影响:低能量低频场抑制对甲状旁腺激素的反应
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4180-4. doi: 10.1073/pnas.79.13.4180.
10
Nonlinear wave mechanisms in interactions between excitable tissue and electromagnetic fields.可兴奋组织与电磁场相互作用中的非线性波动机制。
Neurol Res. 1982;4(1-2):115-53. doi: 10.1080/01616412.1982.11739619.