通过对三个平民队列的表观遗传学荟萃分析，确定 NRG1 和 HGS 为创伤后应激障碍的基于血液的生物标志物。
Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder.
机构信息
Carl R Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL 61801, USA.
Department of Psychology, University of Illinois Urbana-Champaign, 603 East Daniel St, Champaign, IL 61820, USA.
出版信息
Epigenomics. 2018 Dec;10(12):1585-1601. doi: 10.2217/epi-2018-0049. Epub 2018 Nov 20.
Abstract
AIM
Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD.
MATERIALS & METHODS: We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium.
RESULTS
Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098).
CONCLUSION
PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.
摘要
目的
创伤暴露是创伤后应激障碍（PTSD）的一个必要但非决定性的促成因素。表观遗传因素可以区分创伤后暴露个体中是否存在 PTSD。
材料与方法
我们对来自平民背景的创伤后队列中的 PTSD 表观基因组全关联研究进行了荟萃分析。从参与精神疾病基因组学联盟 PTSD 工作组的三个平民队列中抽取的 545 名研究参与者，对其全血来源的 DNA 甲基化水平进行了分析。
结果
NRG1（cg23637605）和 HGS（cg19577098）中的两个 CpG 位点与当前 PTSD 显著相关。
结论
在三个平民队列中，HGS 和 NRG1 中的血液测量到 PTSD 与差异甲基化有关。
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