Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.
Center for Developmental Biology & Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA.
G3 (Bethesda). 2023 Sep 30;13(10). doi: 10.1093/g3journal/jkad177.
There is increasing interest in the African spiny mouse (Acomys cahirinus) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality reference genome is needed to better understand these regenerative properties at the molecular level. Here, we present an improved reference genome for A. cahirinus generated from long Nanopore sequencing reads. We confirm the quality of our annotations using RNA sequencing data from 4 different tissues. Our genome is of higher contiguity and quality than previously reported genomes from this species and will facilitate ongoing efforts to better understand the regenerative properties of this organism.
人们对非刺毛鼠（Acomys cahirinus）越来越感兴趣，因为它在皮肤、肌肉和肾脏等内部器官受伤后具有组织再生的能力。为了更好地从分子水平理解这些再生特性，需要一个高质量的参考基因组。在这里，我们提出了一种来自长纳米孔测序reads 的非洲刺毛鼠改良参考基因组。我们使用来自 4 种不同组织的 RNA 测序数据来验证我们注释的质量。与之前报道的该物种基因组相比，我们的基因组具有更高的连续性和质量，将有助于更好地理解该生物体的再生特性。
