Sanyu Africa Research Institute (SAfRI), Mbale Regional Referral Hospital, Pallisa-Kumi Road Junction, P.o Box 2190, Mbale, Uganda.
Sanyu Research Unit, Department of Women's and Children's Health, University of Liverpool c/o Liverpool Women's Hospital, Crown Street, Liverpool, L8 7SS, UK.
BMC Public Health. 2018 Nov 20;18(1):1279. doi: 10.1186/s12889-018-6201-3.
Neonatal sepsis causes 0.5 million deaths annually, mostly in low resource settings. Babies born in African rural homes without running water or toilet facilities are especially vulnerable. Alcohol-based hand rub (ABHR) may be used by mothers and carers as an alternative to hand washing with soap to prevent neonatal infection. However, no definite study has established the preferred formulation of hand rub for the mothers. This study aimed to assess the effects of addition of bitterants and perfume towards the acceptability of the alcohol-based hand rubs by the mothers in their homes after childbirth.
This was a 3-way blinded cross-over study design. Mothers with children aged ≤3 months were recruited from immunisation clinics at 3 local health facilities in rural eastern Uganda and received 3-different ABHR formulations (in the order plain, bitterant and perfumed) packed in 100 ml bottles. Each ABHR was used for 5 consecutive days followed by a 2-day 'washout' period (evaluation period). Overall satisfaction with each hand rub was evaluated at the end of each week using a 7-point Likert scale.
A total of 43 women were recruited, whose ages ranged from 16 to 45 years (mean 26.2 years old). None of the participants normally used a hand protective lotion/cream. The three formulations were used for a mean of 5 (range 3-7) days. A significantly greater volume of the "bitterant" and "perfumed" formulations (mean 91 and 83 ml respectively) were used in comparison to the "plain" formulation (mean 64 ml). Overall satisfaction was high with all the hand rubs, but the perfumed formulation had a significantly higher overall satisfaction score [mean 6.7, range 4-7] compared with the plain [6.4, 3-7] and bitterant [6.2, 2-7] formulations.
All the 3 ABHR formulations were well accepted with little to choose between them. The ABHR with added perfume scored highest on overall satisfaction and was used significantly more often than plain ABHR. ABHR with bitterant additive did, however, score highly and may be a preferable choice to those with concern over alcohol misuse.
ISRCTN67852437 , prospectively registered on 18/03/2018.
新生儿败血症每年导致 50 万人死亡，主要发生在资源匮乏的环境中。在没有自来水或厕所设施的非洲农村家庭中出生的婴儿尤其容易受到感染。母亲和照顾者可能会使用酒精基手部消毒剂（ABHR）代替肥皂洗手，以预防新生儿感染。然而，尚无明确的研究确定母亲使用哪种手部消毒剂配方。本研究旨在评估在乌干达农村地区的 3 个当地卫生设施的免疫接种诊所中招募的出生后 ≤3 个月大的儿童的母亲对添加苦味剂和香料的 ABHR 的接受程度。
这是一项三向双盲交叉研究设计。参与者为 3 个当地卫生设施的免疫接种诊所中年龄在 3 个月以下的儿童的母亲，她们收到 3 种不同的 ABHR 配方（按普通、苦味剂和加香的顺序），装在 100 毫升的瓶子中。每种 ABHR 使用连续 5 天，然后进行 2 天的“洗脱”期（评估期）。每周结束时，使用 7 分制李克特量表评估对每种手部消毒剂的总体满意度。
共招募了 43 名女性，年龄在 16 至 45 岁之间（平均 26.2 岁）。没有参与者通常使用手部保护乳液/霜。这三种配方的使用平均为 5 天（范围 3-7 天）。与普通配方（平均 64 毫升）相比，“苦味剂”和“加香”配方的使用量明显更大（分别为平均 91 和 83 毫升）。所有手部消毒剂的总体满意度都很高，但与普通和苦味剂配方相比，加香配方的总体满意度评分明显更高[平均 6.7，范围 4-7]。
所有 3 种 ABHR 配方都得到了很好的接受，它们之间几乎没有什么区别。添加香料的 ABHR 在总体满意度方面得分最高，而且比普通 ABHR 使用得更频繁。然而，添加苦味剂的 ABHR 也得分很高，对于那些担心酒精滥用的人来说，可能是一个更好的选择。
ISRCTN67852437，于 2018 年 3 月 18 日前瞻性注册。
