Bouvet J, Cariou C, Poulard A, Oberli F, Cupillard L, Guigal P M
Boehringer Ingelheim Animal Health, Centre de Recherche de Saint-Vulbas, Parc Industriel de la Plaine de l'Ain, 805 Allée des Cyprès, 01150, Saint-Vulbas, France.
Boehringer Ingelheim Animal Health, Lyon Porte des Alpes, rue de l'aviation, 69800, Saint-Priest, France.
Vet Immunol Immunopathol. 2018 Nov;205:93-96. doi: 10.1016/j.vetimm.2018.11.001. Epub 2018 Nov 2.
In many cicumstances, veterinarians are requiring to be able to administer rabies vaccine in dogs at the same time as vaccinating against canine distemper, adenovirus, parvovirus, parainfluenza virus and leptospirosis. The aim of this study was to assess the compatibility between a multivalent vaccine and a rabies vaccine when injected at two separate sites. Lack of interference was assessed by comparing serological response to viral components during one year following primary vaccination with vaccines administered alone or concomitantly. Antibody response to all tested components was comparable, irrespective of whether vaccines were administered individually or concurrently. Notably, the rabies vaccine induced very strong and protective seroconversion in dogs, whether it was administered concomitantly with the combo vaccine or not. This facilitates administration of rabies vaccine, which is a key factor for controlling the disease.
在许多情况下，兽医需要能够在给狗接种犬瘟热、腺病毒、细小病毒、副流感病毒和钩端螺旋体疫苗的同时接种狂犬病疫苗。本研究的目的是评估多价疫苗和狂犬病疫苗在两个不同部位注射时的兼容性。通过比较初次接种疫苗后一年内单独或同时接种疫苗时对病毒成分的血清学反应来评估是否存在干扰。无论疫苗是单独接种还是同时接种，对所有测试成分的抗体反应都是可比的。值得注意的是，狂犬病疫苗在狗身上诱导了非常强烈的保护性血清转化，无论它是否与联合疫苗同时接种。这便于狂犬病疫苗的接种，而接种是控制该疾病的关键因素。
