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Comparison of practical application steps of the previously used adrenaline auto injector in Turkey (EpiPen) and the currently available adrenaline auto injector (Penepin): a multi-center study.土耳其先前使用的肾上腺素自动注射器(EpiPen)与目前可用的肾上腺素自动注射器(Penepin)实际应用步骤的比较:一项多中心研究。
Turk Pediatri Ars. 2018 Sep 1;53(3):149-154. doi: 10.5152/TurkPediatriArs.2018.6734. eCollection 2018 Sep.
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Epinephrine delivery via EpiPen Auto-Injector or manual syringe across participants with a wide range of skin-to-muscle distances.通过肾上腺素笔自动注射器或手动注射器,在皮肤到肌肉距离范围广泛的参与者中注射肾上腺素。
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1
Demonstration of epinephrine autoinjectors (EpiPen and Anapen) by pharmacists in a randomised, simulated patient assessment: acceptable, but room for improvement.药剂师在随机模拟患者评估中演示肾上腺素自动注射器(EpiPen和Anapen):可以接受,但仍有改进空间。
Allergy Asthma Clin Immunol. 2014 Sep 19;10(1):49. doi: 10.1186/1710-1492-10-49. eCollection 2014.
2
Auvi-Q versus EpiPen: preferences of adults, caregivers, and children.奥维尤(Auvi-Q)与依比林(EpiPen):成人、照护者和儿童的选择偏好。
J Allergy Clin Immunol Pract. 2013 May-Jun;1(3):266-72.e1-3. doi: 10.1016/j.jaip.2013.02.004. Epub 2013 Apr 9.
3
Effect of epinephrine autoinjector design on unintentional injection injury.肾上腺素自动注射器设计对非故意注射损伤的影响。
Allergy Asthma Proc. 2012 Nov-Dec;33(6):488-92. doi: 10.2500/aap.2012.33.3609.
4
A real-life study on acquired skills from using an adrenaline autoinjector.使用肾上腺素自动注射器获得技能的真实研究。
Int Arch Allergy Immunol. 2013;160(3):301-6. doi: 10.1159/000341367. Epub 2012 Oct 18.
5
Make-up of the epinephrine autoinjector: the effect on its use by untrained users.肾上腺素自动注射器的组成:对未经训练的使用者使用它的影响。
Pediatr Allergy Immunol. 2011 Nov;22(7):729-33. doi: 10.1111/j.1399-3038.2011.01195.x. Epub 2011 Jul 13.
6
Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.过敏反应的定义与管理第二次研讨会:总结报告——第二届美国国立过敏与传染病研究所/食物过敏与过敏反应网络研讨会
J Allergy Clin Immunol. 2006 Feb;117(2):391-7. doi: 10.1016/j.jaci.2005.12.1303.
7
Anaphylaxis, killer allergy: long-term management in the community.过敏反应,致命性过敏:社区中的长期管理
J Allergy Clin Immunol. 2006 Feb;117(2):367-77. doi: 10.1016/j.jaci.2005.12.002.
8
Parental use of EpiPen for children with food allergies.父母为食物过敏儿童使用肾上腺素自动注射器(EpiPen)。
J Allergy Clin Immunol. 2005 Jul;116(1):164-8. doi: 10.1016/j.jaci.2005.03.039.
9
Use assessment of self-administered epinephrine among food-allergic children and pediatricians.食物过敏儿童和儿科医生中自我注射肾上腺素的使用评估。
Pediatrics. 2000 Feb;105(2):359-62. doi: 10.1542/peds.105.2.359.

土耳其先前使用的肾上腺素自动注射器(EpiPen)与目前可用的肾上腺素自动注射器(Penepin)实际应用步骤的比较:一项多中心研究。

Comparison of practical application steps of the previously used adrenaline auto injector in Turkey (EpiPen) and the currently available adrenaline auto injector (Penepin): a multi-center study.

作者信息

Topal Erdem, Karagöl Hacer İlbilge Ertoy, Yılmaz Özlem, Arga Mustafa, Köksal Burcu, Yılmaz Özlem Özbek, Anıl Hülya, Harmancı Koray, Kutluğ Şeyhan, Öztürk Fadıl, Razi Hasan Cem, Türktaş İpek, Demirsoy Mehmet Sadık, Bakırtaş Arzu

机构信息

Department of Pediatrics, Division of Pediatric Allergy and Asthma, İnönü University School of Medicine, Malatya Turkey.

Department of Pediatrics, Division of Pediatric Allergy and Asthma, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey.

出版信息

Turk Pediatri Ars. 2018 Sep 1;53(3):149-154. doi: 10.5152/TurkPediatriArs.2018.6734. eCollection 2018 Sep.

DOI:10.5152/TurkPediatriArs.2018.6734
PMID:30459513
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6239072/
Abstract

AIM

It has been shown by a great number of studies that the correct use of adrenaline auto injectors prescribed to patients with anaphylaxis is associated with the design of the auto injector, in addition to training. The aim of this study was to compare the skills of adults in using two different auto injectors prescribed to patients with anaphylaxis.

MATERIAL AND METHODS

Parents of patients aged between 1 and 18 years who referred to allergy outpatients were included in the study.

RESULTS

A total of 630 volunteers from nine centers were included in the study. Four hundred fifty-seven (72.5%) of the participants were females and 235 (37.3%) were undergraduates. The rate of showing all the steps of auto injector trainers correctly by the participants was found as (60.2%) (n=379) for EpiPen and 42.9% (n=270) for Penepin (p<0.001). The most frequent mistake with both auto injector trainers was the step of "place appropriate injection tip into outer thigh/press the trigger so it clicks." When the preferences of the volunteers were asked after training and application, 527 (83.7%) chose EpiPen, stating that it was easier and simpler to use.

CONCLUSIONS

Our study showed that the correct usage rates of both adrenaline auto injectors were much lower than expected and there could be mistakes in the application of both. It could be appropriate to make improvements in the design of Penepin, which is still the only available adrenaline auto injector in Turkey, such that its application steps will be simpler and quicker.

摘要

目的

大量研究表明,除培训外,给过敏反应患者开具的肾上腺素自动注射器的正确使用与自动注射器的设计有关。本研究的目的是比较成年人使用给过敏反应患者开具的两种不同自动注射器的技能。

材料与方法

纳入到过敏门诊就诊的1至18岁患者的父母参与本研究。

结果

本研究共纳入了来自9个中心的630名志愿者。参与者中有457名(72.5%)为女性,235名(37.3%)为本科生。发现参与者正确展示肾上腺素自动注射器训练器所有步骤的比例,EpiPen为60.2%(n = 379),Penepin为42.9%(n = 270)(p<0.001)。两种肾上腺素自动注射器训练器最常见的错误是“将合适的注射头放在大腿外侧/按下扳机使其发出咔嗒声”这一步骤。在训练和使用后询问志愿者的偏好时,527名(83.7%)选择了EpiPen,称其使用起来更轻松、更简单。

结论

我们的研究表明,两种肾上腺素自动注射器的正确使用率均远低于预期,且两者在使用中都可能出现错误。对于Penepin(土耳其唯一可用的肾上腺素自动注射器)的设计进行改进,使其使用步骤更简单、更快捷,可能是合适的。