Key Laboratory of Infection and Immunity of Shandong Province, Department of Immunology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Department of Medicine and Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Front Immunol. 2018 Oct 30;9:2509. doi: 10.3389/fimmu.2018.02509. eCollection 2018.
Adipose tissue performs immunoregulatory functions in addition to fat storage. Various T cells in different fat depots either help maintain metabolic homeostasis under healthy conditions or contribute to metabolic disorders in pathological conditions such as obesity, diabetes, cardiovascular diseases, or even cancer. These T cells play critical roles in immunometabolism, which refers to the intersection of immunity and metabolism. Numerous studies have examined the presence and changes of different T cell subsets, including helper T cells, regulatory T cells, cytotoxic T cells, and natural killer T cells, in adipose depots in health and diseases. In this review, we will discuss the adipose tissue niches that influence the patterns and functions of T cell subsets and in turn the impact of these T cells on cell- or body-based immunometabolism accounting for health and obesity.
脂肪组织除了储存脂肪外，还具有免疫调节功能。不同脂肪组织中的各种 T 细胞，要么在健康条件下帮助维持代谢稳态，要么在肥胖、糖尿病、心血管疾病甚至癌症等病理条件下导致代谢紊乱。这些 T 细胞在免疫代谢中发挥着关键作用，免疫代谢是指免疫和代谢的交叉。大量研究已经检查了在健康和疾病状态下，不同 T 细胞亚群（包括辅助性 T 细胞、调节性 T 细胞、细胞毒性 T 细胞和自然杀伤 T 细胞）在脂肪组织中的存在和变化。在这篇综述中，我们将讨论影响 T 细胞亚群模式和功能的脂肪组织生态位，以及这些 T 细胞反过来对基于细胞或基于机体的免疫代谢的影响，包括健康和肥胖。
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