Hwang Se Hwan, Song Jee Nam, Jeong Yeon Min, Lee Yeon Ji, Kang Jun Myung
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Bucheon St. Mary's Hospital, 2 Sosa-dong, Wonmi-gu, Bucheon, Gyeonggi, 420-717, Republic of Korea.
Eur Arch Otorhinolaryngol. 2016 Apr;273(4):811-8. doi: 10.1007/s00405-014-3433-4. Epub 2014 Dec 19.
Postoperative pain and wound healing following tonsillectomy can result in dissatisfaction for the patient. However, there is no consensus on whether postoperatively administered honey effectively reduces morbidity after tonsillectomy. Therefore, a systematic review with a meta-analysis of the efficacy of honey as a treatment for postoperative pain and wound healing was performed. Two authors independently searched the database records (MEDLINE, SCOPUS, and Cochrane databases) dating from inception to June 2014. Studies comparing postoperative oral administration of honey with administration of placebo where the outcomes of interest were pain and wound healing on postoperative days were included. Baseline study characteristics, study quality, numbers of patients in steroid-treated and control groups, and treatment outcomes were extracted. Sufficient data for meta-analysis were retrieved from 4 trials with a total of 264 patients. We analyzed patient-reported pain scores and quantities of administered analgesics during the first 5 postoperative days. The pain score was significantly decreased in the honey-treated patients in comparison with the placebo-treated patients on postoperative day 1 only, but the analgesic intake of the honey-treated patients on the first 5 postoperative days was significantly less than that of the placebo-treated patients. In addition, honey significantly increased tonsillectomy bed wound healing in comparison with placebo during the first 2 weeks after surgery. This meta-analysis shows that postoperative administration of honey after tonsillectomy significantly reduces pain and promotes wound healing. Further trials comparing honey with good research methodology should be conducted to confirm these results.
扁桃体切除术后的疼痛和伤口愈合可能会导致患者不满意。然而，对于术后给予蜂蜜是否能有效降低扁桃体切除术后的发病率，目前尚无共识。因此，我们进行了一项系统评价，并对蜂蜜治疗术后疼痛和伤口愈合的疗效进行了荟萃分析。两位作者独立检索了从数据库建立至2014年6月的记录（MEDLINE、SCOPUS和Cochrane数据库）。纳入了比较术后口服蜂蜜与给予安慰剂的研究，其中感兴趣的结局是术后几天的疼痛和伤口愈合情况。提取了基线研究特征、研究质量、接受类固醇治疗组和对照组的患者数量以及治疗结局。从4项试验中检索到了足够进行荟萃分析的数据，共264例患者。我们分析了患者报告的术后前5天的疼痛评分和给予的镇痛药数量。仅在术后第1天，与接受安慰剂治疗的患者相比，接受蜂蜜治疗的患者疼痛评分显著降低，但接受蜂蜜治疗的患者术后前5天的镇痛药摄入量显著低于接受安慰剂治疗的患者。此外，与安慰剂相比，在手术后的前2周内，蜂蜜显著促进了扁桃体切除部位的伤口愈合。这项荟萃分析表明，扁桃体切除术后给予蜂蜜可显著减轻疼痛并促进伤口愈合。应进行进一步的试验，采用良好的研究方法比较蜂蜜与其他治疗方法，以证实这些结果。
