Department of Obstetrics and Gynecology, University Hospital of Bern and University of Bern, Bern, Switzerland.
Surgical and Medical Department of Translational Medicine, Sapienza University of Rome, Rome, Italy.
J Cancer Res Clin Oncol. 2019 Jan;145(1):213-221. doi: 10.1007/s00432-018-2792-4. Epub 2018 Nov 20.
In several malignancies, it has been demonstrated that the lymph nodal status is the most important pathologic factor affecting prognosis and giving the indication to further adjuvant treatment. The surgical assessment of the lymph nodal status in endometrial cancer is debated since 30 years. Recently, the sentinel lymph node mapping is rapidly gaining clinical acceptance in endometrial cancer. The adoption of Indocyanine Green as a safe and user friendly tracer for sentinel lymph node mapping increased the speed to which this procedure is getting applied in clinical practice. As a consequence of this rapid growth, several fundamental questions have been raised and are still debatable. In this manuscript, we discuss the importance of a known pathological lymph nodal status, the technique of the sentinel lymph node mapping with the reported false negative rates and detection rates according to the different tracers adopted, and the clinical scenarios in which a sentinel lymph node mapping could be employed.
在几种恶性肿瘤中，已经证实淋巴结状态是影响预后的最重要的病理因素，并为进一步辅助治疗提供了依据。关于子宫内膜癌的淋巴结状态的外科评估已经争论了 30 年。最近，前哨淋巴结绘图在子宫内膜癌中迅速获得临床认可。吲哚菁绿作为一种安全且易于使用的前哨淋巴结示踪剂，提高了该方法在临床实践中的应用速度。由于这种快速增长，出现了一些基本问题，目前仍存在争议。在本文中，我们讨论了已知的病理性淋巴结状态的重要性、不同示踪剂的前哨淋巴结绘图技术以及报告的假阴性率和检测率，以及前哨淋巴结绘图可以应用的临床场景。
