法国在施氏鼠耳蝠中分离到莱里达蝙蝠狂犬病病毒
Lleida Bat Lyssavirus isolation in Miniopterus schreibersii in France.
作者信息
Picard-Meyer Evelyne, Beven Veronique, Hirchaud Edouard, Guillaume Cédric, Larcher Gérald, Robardet Emmanuelle, Servat Alexandre, Blanchard Yannick, Cliquet Florence
机构信息
ANSES-Nancy Laboratory for Rabies and Wildlife, Malzéville, France.
ANSES-Ploufragan, Ploufragan, France.
出版信息
Zoonoses Public Health. 2019 Mar;66(2):254-258. doi: 10.1111/zph.12535. Epub 2018 Nov 20.
Bat rabies cases are attributed in Europe to five different Lyssavirus species of 16 recognized Lyssavirus species causing rabies. One of the most genetically divergent Lyssavirus spp. has been detected in a dead Miniopterus schreibersii bat in France. Brain samples were found positive for the presence of antigen, infectious virus and viral RNA by classical virological methods and molecular methods respectively. The complete genome sequence was determined by next-generation sequencing. The analysis of the complete genome sequence confirmed the presence of Lleida bat lyssavirus (LLEBV) in bats in France with 99.7% of nucleotide identity with the Spanish LLEBV strain (KY006983).
在欧洲，蝙蝠狂犬病病例归因于16种已确认的能引发狂犬病的狂犬病毒属病毒中的5种不同病毒。在法国一只死亡的施氏鼠耳蝠中检测到了遗传差异最大的狂犬病毒属病毒之一。通过经典病毒学方法和分子方法分别发现脑样本中存在抗原、传染性病毒和病毒RNA。通过下一代测序确定了完整的基因组序列。对完整基因组序列的分析证实，法国蝙蝠中存在莱里达蝙蝠狂犬病毒（LLEBV），与西班牙LLEBV毒株（KY006983）的核苷酸同一性为99.7%。
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