Krembil Research Institute, Toronto Western Hospital.
Centre for Vision Research, York University.
J Glaucoma. 2019 Jan;28(1):68-74. doi: 10.1097/IJG.0000000000001121.
Our lab has previously shown that patients with early glaucoma have longer vection latencies than controls. We attempted to explain this finding using a combined index of structure and function (CSFI), as proposed by Medeiros and colleagues. The CSFI estimates the proportion of retinal ganglion cell loss.
Roll and circular vection were evoked using a back-projected screen (experiment 1) and the Oculus Rift system (experiment 2). Vection latency and duration were measured using a button response box. In experiment 1, tilt angles were measured with a tilt sensor, whereas subjective tilt was determined using a joystick attached to a protractor. In experiment 2, subjective vection strength was rated on a 1 to 10 scale. These measurements were compared with the CSFI, which utilizes visual field and optical coherence tomography data.
For experiment 1 we tested 22 patients (mean age, 70.3±6 y) with glaucoma and 18 controls (mean age, 54.6±9 y); and for experiment 2 we tested 24 patients (mean age, 71.1 ±5 y) and 23 controls (mean age 61.4±10 y), but not all patients experienced vection. In both experiments, vection latency was significantly longer for patients than for controls (smallest P=0.02). The CSFI was not related to vection latency, duration, or objective and subjective measures of vection strength (smallest P=0.06) in either experiment.
Two experiments have replicated the finding that vection responses are longer in patients with glaucoma than in controls; however, the CSFI is not related to vection responses.
我们实验室之前的研究表明，早期青光眼患者的视动延迟时间长于对照组。我们试图使用 Medeiros 及其同事提出的结构和功能综合指数 (CSFI) 来解释这一发现。CSFI 估计了视网膜神经节细胞损失的比例。
使用背投屏幕（实验 1）和 Oculus Rift 系统（实验 2）诱发滚动和圆形视动。使用按钮响应盒测量视动延迟和持续时间。在实验 1 中，倾斜角度使用倾斜传感器测量，而主观倾斜使用连接到量角器的操纵杆确定。在实验 2 中，主观视动强度评分为 1 到 10 级。这些测量值与 CSFI 进行了比较，CSFI 利用视野和光学相干断层扫描数据。
在实验 1 中，我们测试了 22 名青光眼患者（平均年龄 70.3±6 岁）和 18 名对照组（平均年龄 54.6±9 岁）；在实验 2 中，我们测试了 24 名患者（平均年龄 71.1 ±5 岁）和 23 名对照组（平均年龄 61.4±10 岁），但并非所有患者都出现视动。在两个实验中，患者的视动延迟时间明显长于对照组（最小 P=0.02）。在两个实验中，CSFI 与视动延迟时间、持续时间或视动强度的客观和主观测量均无关（最小 P=0.06）。
两个实验均复制了青光眼患者的视动反应长于对照组的发现；然而，CSFI 与视动反应无关。
