Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong.
Department of Sports Science and Physical Education, Faculty of Education, The Chinese University of Hong Kong.
Age Ageing. 2019 Mar 1;48(2):220-228. doi: 10.1093/ageing/afy179.
Limited trials examining the effect of exercise and nutrition supplementation in older people with sarcopenia are available.
to assess the impact of resistance exercise program targeting muscle strength and power with and without nutrition supplementation on gait speed, body composition, physical function and quality of life.
this trial randomized 113 community-dwelling older Chinese adults aged ≥65 and with sarcopenia defined using the Asian Criteria into one of the three groups: exercise program alone, combined-exercise program and nutrition supplement or waitlist control. The exercise program consisted of 90-min group training twice weekly and one-home session weekly for 12 weeks. Participants in the combined group were additionally asked to consume nutrition supplement twice daily for 12 weeks. Both groups were encouraged to keep home exercise after intervention period for another 12 weeks to detect sustained effect. The primary outcome was gait speed.
at 12 and 24 weeks, gait speed did not differ significantly between groups. Significant improvement in leg extension, and five-chair stand test occurred in both intervention groups that persisted to 24 weeks. Physical Activity Scale for the Elderly improved in both intervention groups that persisted until 24 weeks only in the combined group. Lower limb muscle and appendicular skeletal muscle mass increased significantly in the combined group but the increase was not sustained to 24 weeks.
the exercise program with and without nutrition supplementation had no significant effect on the primary outcome of gait speed but improved the secondary outcomes of strength and the five-chair stand test in community-dwelling Chinese sarcopenic older adults.
CLINICALTRIALS.GOV IDENTIFIER: NCT02374268.
目前仅有少数试验研究了运动和营养补充对老年肌少症患者的影响。
评估针对肌肉力量和力量的抗阻运动方案以及是否补充营养对步态速度、身体成分、身体功能和生活质量的影响。
本试验将 113 名居住在社区的≥65 岁且符合亚洲标准的肌少症老年人随机分为三组：单独运动方案组、联合运动方案和营养补充组或候补对照组。运动方案包括每周两次 90 分钟的小组训练和每周一次的家庭训练，共 12 周。联合组的参与者还被要求在 12 周内每天补充两次营养补充剂。两组均鼓励在干预期后继续进行家庭锻炼 12 周，以检测持续效果。主要结局指标为步态速度。
在 12 周和 24 周时，各组之间的步态速度没有显著差异。两个干预组的腿部伸展和 5 次椅子站立测试均有显著改善，且持续到 24 周。只有联合组的老年人活动量表在两个干预组中均有所改善，且持续到 24 周。下肢肌肉和四肢骨骼肌肉质量在联合组中显著增加，但到 24 周时增加不再持续。
运动方案联合或不联合营养补充对步态速度这一主要结局没有显著影响，但改善了社区居住的中国肌少症老年人的力量和 5 次椅子站立测试这两个次要结局。
NCT02374268。
