Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tokyo, Japan.
National Center for Geriatrics and Gerontology, Morioka, Japan.
Geriatr Gerontol Int. 2019 May;19(5):429-437. doi: 10.1111/ggi.13643. Epub 2019 Mar 13.
The objective of this trial was to investigate the synergistic effects of bodyweight resistance exercise and a protein supplement with vitamin D on skeletal muscle in sarcopenic or dynapenic older adults.
This was a four-arm randomized controlled trial. Sarcopenic or dynapenic older adults were recruited for this trial. After screening, a total of 112 older adults were randomly allocated among four groups; 28 older adults each were enrolled in the combined resistance exercise and nutritional supplementation group, the exercise alone group, the nutritional supplementation alone group, and the control group. Participants in the combined group and exercise alone groups took part in a bodyweight resistance exercise program for 12 weeks. Protein and vitamin D supplements were provided every day for 12 weeks for the participants in the combined group and nutritional supplementation alone groups. We assessed the echo intensity of participants' thigh muscle using ultrasonography, measured their appendicular muscle mass using a bioelectrical impedance data acquisition system, and tested their knee extension strength and physical function.
Participants in the combined group had a significantly greater improvement in rectus femoris echo intensity and knee extension torque than those in the other groups (P < 0.05). Furthermore, the combined program increased appendicular muscle mass in sarcopenic older adults (P < 0.05), but not in older adults with low physical function with normal muscle mass.
The present study confirmed the synergistic effect of bodyweight resistance exercise and protein supplement with vitamin D on muscle quality and muscle strength in sarcopenic or dynapenic older adults. Geriatr Gerontol Int 2019; 19: 429-437.
本试验旨在研究抗阻运动与维生素 D 补充剂联合应用对肌肉减少症或动力缺乏老年人骨骼肌的协同作用。
这是一项四臂随机对照试验。招募了肌肉减少症或动力缺乏的老年人参加本试验。经过筛选，共有 112 名老年人被随机分为四组；每组 28 名老年人，分别纳入联合抗阻运动和营养补充组、单纯运动组、单纯营养补充组和对照组。联合组和单纯运动组的参与者参加了为期 12 周的抗阻运动方案。联合组和单纯营养补充组的参与者每天接受为期 12 周的蛋白质和维生素 D 补充。我们使用超声评估参与者大腿肌肉的回声强度，使用生物电阻抗数据采集系统测量四肢肌肉质量，并测试他们的膝关节伸展力量和身体功能。
联合组的股直肌回声强度和膝关节伸展扭矩的改善明显大于其他组（P<0.05）。此外，联合方案增加了肌肉减少症老年人的四肢肌肉质量（P<0.05），但对肌肉质量正常、身体功能较低的老年人没有影响。
本研究证实了抗阻运动与维生素 D 补充剂联合应用对肌肉减少症或动力缺乏老年人的肌肉质量和肌肉力量的协同作用。老年医学与老年病学杂志 2019；19：429-437。
