Liu Minjing, Li Jiaojiao, Xu Jing, Chen Ya, Chien Chiafu, Zhang Hui, Zhang Qing, Wang Li
Department of Nursing, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
School of Nursing, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.
Clin Interv Aging. 2024 Sep 26;19:1581-1595. doi: 10.2147/CIA.S473081. eCollection 2024.
This randomized parallel controlled trial aimed to determine the effectiveness of graded progressive home-based resistance combined with aerobic exercise in improving physical fitness in community-dwelling older adults with sarcopenia.
Community-dwelling older adults (≥60 years) with sarcopenia were randomly assigned to the intervention group (IG), receiving 12 weeks of graded progressive home-based resistance and aerobic exercise training, and the control group (CG), maintaining lifestyle unchanged. The primary outcomes were knee extensor muscle strength and the six-minute walk distance (6MWD). Intention-to-treat analysis was applied to the data from all participants in the CG and IG. Post-intervention differences between the intervention and control groups were determined using a generalized estimated equation model with pre-values adjusted.
Data from all the participants in the IG (n=41) and CG (n=45) were analyzed. After the intervention, knee extensor muscle strength (95% CI: 0.140-3.460, =0.036), 6MWD (95% CI: 35.350-80.010, <0.001), flexor muscle strength and the results of 30s bicep curls, 30s chair stand, the chair sit and reach test and back stretch test in the IG were larger and value of the timed up-and-go test was smaller than those in the CG (<0.05). The body composition, quality of life and their changes showed no group differences. The attendance rates were 82.9% and 85.4% for resistance and aerobic exercise, respectively.
The 12-week graded progressive home-based resistance and aerobic exercise intervention improved muscle strength, balance, flexibility, and cardiorespiratory fitness in community-dwelling older adults with sarcopenia, whereas body composition and quality of life remained unchanged. The research was approved by the Ethics Committee of Soochow University (ECSU-2019000161) and registered at the Chinese Clinical Trial Registry (ChiCTR1900027960, http://www.chictr.org.cn/showproj.aspx?proj=45968).
本随机平行对照试验旨在确定分级渐进式居家抗阻训练联合有氧运动对改善社区居家肌少症老年人身体素质的有效性。
将社区居家的肌少症老年人（≥60岁）随机分为干预组（IG），接受为期12周的分级渐进式居家抗阻和有氧运动训练，以及对照组（CG），保持生活方式不变。主要结局指标为膝伸肌力量和6分钟步行距离（6MWD）。对CG和IG所有参与者的数据进行意向性分析。使用调整了预值的广义估计方程模型确定干预组和对照组干预后的差异。
分析了IG（n = 41）和CG（n = 45）所有参与者的数据。干预后，IG的膝伸肌力量（95%CI：0.140 - 3.460，P = 0.036）、6MWD（95%CI：35.350 - 80.010，P < 0.001）、屈肌力量以及30秒二头肌卷曲、30秒椅子站立、椅子坐立前屈试验和背部伸展试验的结果均大于CG，且定时起立行走试验的值小于CG（P < 0.05）。身体成分、生活质量及其变化在两组间无差异。抗阻训练和有氧运动的出勤率分别为82.9%和85.4%。
为期12周的分级渐进式居家抗阻和有氧运动干预改善了社区居家肌少症老年人的肌肉力量、平衡能力、灵活性和心肺适能，而身体成分和生活质量保持不变。本研究经苏州大学伦理委员会批准（ECSU - 2019000161），并在中国临床试验注册中心注册（ChiCTR1900027960, http://www.chictr.org.cn/showproj.aspx?proj=45968）。
