Procaccia S, Lanzanova D, Caputo D, Ferrante P, Papini E, Gasparini A, Colucci A, Bianchi M, Villa P, Blasio R
Institute of Medicine, University of Milan Medical School, Italy.
Acta Neurol Scand. 1988 May;77(5):373-81. doi: 10.1111/j.1600-0404.1988.tb05922.x.
We studied circulating immune complexes (IC) in the serum and cerebrospinal fluid (CSF) of patients with clinically defined multiple sclerosis (MS), in order to establish a correlation with the clinical course of the disease and to investigate the molecular composition of the IC isolated from patients in active phase of the disease. Serum IC levels were found to be significantly increased in patients from the progressive and active relapsing-remittent subgroups with both the CIC-conglutinin and C1q-binding methods. High levels of IC in CSF were detected only in the subgroup consisting of the relapsing-remittent patients in disease exacerbation when IC were determined by the C1q-binding test. No significant increase in serum or in CSF were found using the mRF-I test. The preliminary results of a qualitative investigation on serum IC in MS indicated that they are heterogeneous in nature, their size is mainly of the intermediate type, and they contain IgG, IgM, complement components and beta 2-microglobulins, the latter presenting an observation both new and interesting for studies on serum IC in MS patients.
我们研究了临床确诊的多发性硬化症（MS）患者血清和脑脊液（CSF）中的循环免疫复合物（IC），目的是建立其与疾病临床病程的相关性，并研究从疾病活动期患者分离出的IC的分子组成。采用CIC-胶固素和C1q结合法发现，进展型和复发缓解型活动亚组患者的血清IC水平显著升高。仅在复发缓解型患者疾病加重亚组中，通过C1q结合试验测定时，脑脊液中检测到高水平的IC。使用mRF-I试验未发现血清或脑脊液中有显著增加。对MS患者血清IC的定性研究初步结果表明，它们本质上是异质性的，其大小主要为中间型，并且它们含有IgG、IgM、补体成分和β2-微球蛋白，后者对于MS患者血清IC的研究而言是一个新的且有趣的观察结果。
