Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Leiden University Medical Center, Leiden, the Netherlands.
Immunity. 2018 Nov 20;49(5):801-818. doi: 10.1016/j.immuni.2018.10.016.
Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules that are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential both to transform our understanding of parasite adaptation to the host and to develop possible therapies for immune-mediated disease. In this review we will summarize the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery.
由于能够调节宿主免疫反应，蠕虫是极为成功的寄生虫。它们进化出了一系列免疫调节分子，这些分子正在逐渐被定义，这预示着寄生虫免疫学的分子革命。这些发现有可能改变我们对寄生虫适应宿主的理解，并为免疫介导的疾病开发可能的治疗方法。在这篇综述中，我们将总结寄生虫免疫调节的最新进展，并讨论未来研究和发现的方向。
