寄生虫效应分子的扩展 repertoire：通过蠕虫对宿主免疫的调节。
Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules.
机构信息
Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Leiden University Medical Center, Leiden, the Netherlands.
出版信息
Immunity. 2018 Nov 20;49(5):801-818. doi: 10.1016/j.immuni.2018.10.016.
Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules that are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential both to transform our understanding of parasite adaptation to the host and to develop possible therapies for immune-mediated disease. In this review we will summarize the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery.
由于能够调节宿主免疫反应，蠕虫是极为成功的寄生虫。它们进化出了一系列免疫调节分子，这些分子正在逐渐被定义，这预示着寄生虫免疫学的分子革命。这些发现有可能改变我们对寄生虫适应宿主的理解，并为免疫介导的疾病开发可能的治疗方法。在这篇综述中，我们将总结寄生虫免疫调节的最新进展，并讨论未来研究和发现的方向。
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