Royal Veterinary College, Royal College Street, London NW1 0TU, UK.
Parasite Immunol. 2010 Jan;32(1):1-19. doi: 10.1111/j.1365-3024.2009.01147.x.
Granulocytes are effector cells in defence against helminth infections. We review the current evidence for the role of granulocytes in protective immunity against different helminth infections and note that for each parasite species the role of granulocytes as effector cells can vary. Emerging evidence also points to granulocytes as immunomodulatory cells able to produce many cytokines, chemokines and modulatory factors which can bias the immune response in a particular direction. Thus, the role of granulocytes in an immunomodulatory context is discussed including the most recent data that points to an important role for basophils under this guise.
粒细胞是抵御寄生虫感染的效应细胞。我们回顾了粒细胞在针对不同寄生虫感染的保护性免疫中的作用的现有证据，并指出对于每种寄生虫，粒细胞作为效应细胞的作用可能会有所不同。新出现的证据还表明粒细胞是免疫调节细胞，能够产生许多细胞因子、趋化因子和调节因子，从而使免疫反应偏向特定方向。因此，我们讨论了粒细胞在免疫调节背景下的作用，包括最近的数据表明嗜碱性粒细胞在这种情况下起着重要作用。
