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使用癌胚抗原特异性肿瘤沉淀素小龙虾蛋白对人类肿瘤中癌胚抗原(CEA)进行的免疫组织化学研究

[Immunohistochemical study of the carcinoembryonic antigen (CEA) in human tumors using the CEA-specific oncoprecipitin crustacin].

作者信息

Pugachev K K, Kalashnikov V V, Kurika A V, Pavlenko A F, Belous T A

出版信息

Biull Eksp Biol Med. 1988 Aug;106(8):209-11.

PMID:3046676
Abstract

58 human tumors have been studied immunohistologically with the aid of CEA-specific precipitin--crustacin (Cr). The results were in general similar to those which were achieved with anti-CEA-antibodies. But there were some differences. The reaction with Cr in the cytoplasm was mostly diffuse, while the reaction with Ab was localized usually in the peripheral parts of the cytoplasm. The reaction with Cr has a more restricted character and is more expressed in ovarian tumors and less expressed in gastric and colonic tumors than the reaction with Ab.

摘要

借助癌胚抗原特异性沉淀素——甲壳素(Cr),对58例人类肿瘤进行了免疫组织学研究。结果总体上与使用抗癌胚抗原抗体所获得的结果相似。但也存在一些差异。在细胞质中与Cr的反应大多呈弥漫性,而与抗体的反应通常定位在细胞质的周边部分。与Cr的反应具有更局限的特征,在卵巢肿瘤中比与抗体的反应表达更明显,而在胃和结肠肿瘤中表达较少。

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