College of Life and Environment Science, Huangshan University, Huangshan, PR China.
Department of Food Science and Biotechnology, Andong National University, Andong, Korea.
Nat Prod Res. 2020 Jun;34(12):1786-1790. doi: 10.1080/14786419.2018.1527832. Epub 2018 Nov 23.
Mulberry ( L.) root bark (MRB) was extracted using methanol and the extracts were subjected to tests of anti-inflammatory effects. The ethyl acetate fraction demonstrated the best anti-inflammatory effects. Purified compounds, sanggenon B, albanol B and sanggenon D, showed inhibitory effects on NO production in LPS-stimulated RAW264.7 cells and albanol B demonstrated the best anti-inflammatory effects. Regarding the underlying molecular mechanisms, further investigations showed that treatments with Albanol B reduced production of pro-inflammatory cytokines and decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). These results would contribute to development of novel anti-inflammatory drugs from MRB.
桑树根皮（MRB）用甲醇提取，提取物进行抗炎作用试验。乙酸乙酯部分表现出最好的抗炎作用。纯化的化合物桑根酮 B、阿尔巴诺醇 B 和桑根酮 D 对 LPS 刺激的 RAW264.7 细胞中 NO 的产生有抑制作用，阿尔巴诺醇 B 表现出最好的抗炎作用。关于潜在的分子机制，进一步的研究表明，阿尔巴诺醇 B 的处理降低了促炎细胞因子的产生，降低了诱导型一氧化氮合酶（iNOS）和环氧化酶-2（COX-2）的表达。这些结果将有助于从 MRB 开发新型抗炎药物。
