Neuroendocrine/Pituitary Program, Division of Endocrinology, Diabetes and Metabolism, University of Florida, 1600 Southwest Archer Road, Room H2, PO Box 100226, Gainesville, FL 32610, USA.
Neurol Clin. 2019 Feb;37(1):63-83. doi: 10.1016/j.ncl.2018.09.009.
Pregnancy is associated with alterations in pituitary hormonal function and enlargement of the pituitary gland. Pituitary dysfunction diagnosis can be challenging during pregnancy due to known alterations in hormonal status. Pituitary disorders are relatively common; with advancements in medical care, more women with pituitary disorders are becoming pregnant. Management includes optimization of hormonal function and close monitoring for signs of tumor progression during pregnancy. Tumor-directed medical therapy is generally discontinued during pregnancy but can be reinitiated if there is evidence of tumor growth. Most women do not show aggressive tumor growth during pregnancy and can be managed conservatively until delivery.
妊娠可导致垂体激素功能改变和垂体增大。由于已知的激素状态改变，妊娠期间诊断垂体功能障碍具有挑战性。垂体疾病较为常见；随着医疗保健的进步，越来越多的垂体疾病妇女怀孕。治疗包括优化激素功能，并密切监测妊娠期间肿瘤进展的迹象。妊娠期间一般停止针对肿瘤的药物治疗，但如果有肿瘤生长的证据，可以重新开始。大多数女性在妊娠期间不会出现侵袭性肿瘤生长，可以在分娩前进行保守治疗。
