School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China; Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
J Pharm Biomed Anal. 2019 Feb 5;164:734-741. doi: 10.1016/j.jpba.2018.11.029. Epub 2018 Nov 15.
The flowers of Juglans regia L. have demonstrated their medicinal value as a part of edible plants. In this study, an analytical methodology for identification of flavonoid chemical constituents in flowers of Juglans regia L. was established using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS). Thirty-six flavonoid compounds were identified based on highly accurate mass measurements, and the mass spectrometric fragmentation pathways of eleven representative compounds were proposed, which was helpful for the identification of different types of flavonoids. The study has laid the foundation for the research and development of effective drugs from flowers of Juglans regia L.
山核桃花作为食用植物的一部分，已显示出其药用价值。本研究采用超高效液相色谱-四极杆飞行时间质谱（UHPLC-Q-TOF-MS）建立了山核桃花中类黄酮化学成分的分析方法。基于精确质量测量，鉴定出 36 种类黄酮化合物，并提出了 11 种代表性化合物的质谱裂解途径，这有助于不同类型类黄酮的鉴定。该研究为山核桃花有效药物的研究与开发奠定了基础。
