Phytochemical Analysis, Anti-inflammatory, and Antioxidant Activities of Roots.

root is a traditional medicinal plant in China and used to treat inflammatory diseases for centuries, but its phytochemical profiling and biological functions are still unknown. Thus, a rapid, efficient, and precise method based on ultra high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS/MS) was applied to rapidly analyse the phytochemical profiling of with anti-inflammatory and antioxidant activities . As a result, a total of 78 chemical compositions, including 15 phenylpropanoids, 15 alkaloids, 14 flavonoids, 14 fatty acids, 7 phenols, 4 steroids, 4 cyclic peptides, 3 terpenoids, and 2 others, were identified or tentatively characterized in the roots of . . Moreover, alkaloid and cyclic peptide were reported from . for the first time. In addition, the ethanol crude extract of D. dentiger roots exhibited remarkable anti-inflammatory activity against cyclooxygenase- (COX-) 2 inhibitory and antioxidant activities . This study is the first to explore the phytochemical analysis and COX-2 inhibitory activity of . This study can provide important phytochemical profiles and biological functions for the application of roots as a new source of natural COX-2 inhibitors and antioxidants in pharmaceutical industry.