Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
Biomed Res Int. 2020 Nov 20;2020:5084057. doi: 10.1155/2020/5084057. eCollection 2020.
root is a traditional medicinal plant in China and used to treat inflammatory diseases for centuries, but its phytochemical profiling and biological functions are still unknown. Thus, a rapid, efficient, and precise method based on ultra high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS/MS) was applied to rapidly analyse the phytochemical profiling of with anti-inflammatory and antioxidant activities . As a result, a total of 78 chemical compositions, including 15 phenylpropanoids, 15 alkaloids, 14 flavonoids, 14 fatty acids, 7 phenols, 4 steroids, 4 cyclic peptides, 3 terpenoids, and 2 others, were identified or tentatively characterized in the roots of . . Moreover, alkaloid and cyclic peptide were reported from . for the first time. In addition, the ethanol crude extract of D. dentiger roots exhibited remarkable anti-inflammatory activity against cyclooxygenase- (COX-) 2 inhibitory and antioxidant activities . This study is the first to explore the phytochemical analysis and COX-2 inhibitory activity of . This study can provide important phytochemical profiles and biological functions for the application of roots as a new source of natural COX-2 inhibitors and antioxidants in pharmaceutical industry.
根是中国的一种传统药用植物，几个世纪以来一直被用于治疗炎症性疾病，但它的植物化学特征和生物功能仍不清楚。因此，应用基于超高效液相色谱-四极杆飞行时间串联质谱（UHPLC-Q-TOF-MS/MS）的快速、高效、精确方法，对具有抗炎和抗氧化活性的进行了植物化学特征分析。结果，共鉴定或初步鉴定了 78 种化学成分，包括 15 种苯丙素类、15 种生物碱、14 种类黄酮、14 种脂肪酸、7 种酚类、4 种甾体、4 种环肽、3 种萜类和 2 种其他化合物。此外，生物碱和环肽是首次从 中报道的。此外，龙牙楤木根的乙醇粗提取物对环氧化酶（COX-）-2 抑制和抗氧化活性表现出显著的抗炎活性。本研究首次探讨了 的植物化学分析和 COX-2 抑制活性。本研究可为龙牙楤木根作为医药工业中天然 COX-2 抑制剂和抗氧化剂的新来源提供重要的植物化学特征和生物功能。
