• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

间质性膀胱炎影像学及认识方面的最新进展。

Recent advances in imaging and understanding interstitial cystitis.

作者信息

Tyagi Pradeep, Moon Chan-Hong, Janicki Joseph, Kaufman Jonathan, Chancellor Michael, Yoshimura Naoki, Chermansky Christopher

机构信息

Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.

Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.

出版信息

F1000Res. 2018 Nov 9;7. doi: 10.12688/f1000research.16096.1. eCollection 2018.

DOI:10.12688/f1000research.16096.1
PMID:30473772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6234747/
Abstract

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating condition associated with intense pelvic pain and bladder storage symptoms. Since diagnosis is difficult, prevalence estimates vary with the methodology used. There is also a lack of proven imaging tools and biomarkers to assist in differentiation of IC/BPS from other urinary disorders (overactive bladder, vulvodynia, endometriosis, and prostatitis). Current uncertainty regarding the etiology and pathology of IC/BPS ultimately impacts its timely and successful treatment, as well as hampers future drug development. This review will cover recent developments in imaging methods, such as magnetic resonance imaging, that advance the understanding of IC/BPS and guide drug development.

摘要

间质性膀胱炎/膀胱疼痛综合征（IC/BPS）是一种使人衰弱的病症，伴有强烈的盆腔疼痛和膀胱储尿症状。由于诊断困难，患病率估计因所用方法而异。也缺乏经证实的成像工具和生物标志物来协助将IC/BPS与其他泌尿系统疾病（膀胱过度活动症、外阴痛、子宫内膜异位症和前列腺炎）区分开来。目前关于IC/BPS病因和病理的不确定性最终影响其及时和成功的治疗，也阻碍了未来的药物开发。本综述将涵盖成像方法的最新进展，如磁共振成像，这些进展有助于增进对IC/BPS的理解并指导药物开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/402b/6234747/d27910575e57/f1000research-7-17576-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/402b/6234747/9f2edaa8b8a2/f1000research-7-17576-g0000.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/402b/6234747/46d7ab163401/f1000research-7-17576-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/402b/6234747/79c73ef223fe/f1000research-7-17576-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/402b/6234747/d27910575e57/f1000research-7-17576-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/402b/6234747/9f2edaa8b8a2/f1000research-7-17576-g0000.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/402b/6234747/46d7ab163401/f1000research-7-17576-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/402b/6234747/79c73ef223fe/f1000research-7-17576-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/402b/6234747/d27910575e57/f1000research-7-17576-g0003.jpg

相似文献

1
Recent advances in imaging and understanding interstitial cystitis.间质性膀胱炎影像学及认识方面的最新进展。
F1000Res. 2018 Nov 9;7. doi: 10.12688/f1000research.16096.1. eCollection 2018.
2
Diffusion-Weighted Magnetic Resonance Imaging: A New Tool for the Diagnosis of Bladder Pain Syndrome/Interstitial Cystitis.扩散加权磁共振成像：诊断膀胱疼痛综合征/间质性膀胱炎的新工具。
Urol Int. 2019;102(1):109-112. doi: 10.1159/000493507. Epub 2018 Nov 14.
3
Unsupervised Machine Learning Reveals a Vulvodynia-Predominant Subtype in Bladder Pain Syndrome/Interstitial Cystitis.无监督机器学习揭示了膀胱疼痛综合征/间质性膀胱炎中以外阴痛为主的亚型。
Cureus. 2024 Jun 18;16(6):e62585. doi: 10.7759/cureus.62585. eCollection 2024 Jun.
4
Symptomatic overlap in overactive bladder and interstitial cystitis/bladder pain syndrome: development of a new algorithm.症状重叠的膀胱过度活动症和间质性膀胱炎/膀胱疼痛综合征：新算法的发展。
BJU Int. 2019 Apr;123(4):682-693. doi: 10.1111/bju.14568. Epub 2018 Oct 24.
5
In vivo and ex vivo assessment of bladder hyper-permeability and using molecular targeted magnetic resonance imaging to detect claudin-2 in a mouse model for interstitial cystitis.体内和体外评估膀胱高通透性，并使用分子靶向磁共振成像在间质性膀胱炎小鼠模型中检测紧密连接蛋白-2。
PLoS One. 2020 Oct 23;15(10):e0239282. doi: 10.1371/journal.pone.0239282. eCollection 2020.
6
Role of Diffusion-Weighted Magnetic Resonance Imaging in the Diagnosis of Bladder Pain Syndrome/Interstitial Cystitis.弥散加权磁共振成像在膀胱疼痛综合征/间质性膀胱炎诊断中的作用。
Urology. 2020 Jul;141:55-59. doi: 10.1016/j.urology.2020.03.019. Epub 2020 Apr 8.
7
Diagnosis of interstitial cystitis/bladder pain syndrome in women with chronic pelvic pain: a prospective observational study.慢性盆腔疼痛女性间质性膀胱炎/膀胱疼痛综合征的诊断：一项前瞻性观察研究。
Int Urogynecol J. 2012 Oct;23(10):1361-6. doi: 10.1007/s00192-012-1711-5. Epub 2012 Mar 8.
8
MRI suggests increased tonicity of the levator ani in women with interstitial cystitis/bladder pain syndrome.磁共振成像显示，间质性膀胱炎/膀胱疼痛综合征女性患者的肛提肌张力增加。
Int Urogynecol J. 2016 Jan;27(1):77-83. doi: 10.1007/s00192-015-2794-6. Epub 2015 Aug 1.
9
Prevalence and correlates of sexual dysfunction among women with bladder pain syndrome/interstitial cystitis.膀胱疼痛综合征/间质性膀胱炎女性性功能障碍的患病率及相关因素。
Urology. 2011 Mar;77(3):576-80. doi: 10.1016/j.urology.2010.10.016. Epub 2011 Jan 7.
10
Pathology and terminology of interstitial cystitis/bladder pain syndrome: A review.间质性膀胱炎/膀胱疼痛综合征的病理学与术语：综述
Histol Histopathol. 2019 Jan;34(1):25-32. doi: 10.14670/HH-18-028. Epub 2018 Jul 17.

引用本文的文献

1
Unraveling the complexity of bladder-centric chronic pain by intravesical contrast enhanced MRI.通过膀胱内对比增强磁共振成像揭示以膀胱为中心的慢性疼痛的复杂性。
Continence (Amst). 2023 Sep;7. doi: 10.1016/j.cont.2023.101041. Epub 2023 Jul 20.
2
Molecular characterization of suburothelial fibrosis in murine acute recurrent bladder inflammation.小鼠急性复发性膀胱炎症中亚上皮纤维化的分子特征
Sci Rep. 2025 Apr 21;15(1):13795. doi: 10.1038/s41598-025-96860-4.
3
Joint Terminology Report: Terminology Standardization for Female Bladder Pain Syndrome.

本文引用的文献

1
Downregulation of WNT11 is associated with bladder tissue fibrosis in patients with interstitial cystitis/bladder pain syndrome without Hunner lesion.WNT11 的下调与 Hunner 病变阴性的间质性膀胱炎/膀胱疼痛综合征患者的膀胱组织纤维化有关。
Sci Rep. 2018 Jun 28;8(1):9782. doi: 10.1038/s41598-018-28093-7.
2
Electron microscopic characteristics of interstitial cystitis/bladder pain syndrome and their association with clinical condition.间质性膀胱炎/膀胱疼痛综合征的电子显微镜特征及其与临床状况的关系。
PLoS One. 2018 Jun 7;13(6):e0198816. doi: 10.1371/journal.pone.0198816. eCollection 2018.
3
Adelmidrol + sodium hyaluronate in IC/BPS or conditions associated to chronic urothelial inflammation. A translational study.
联合术语报告：女性膀胱疼痛综合征的术语标准化
Int Urogynecol J. 2025 Feb;36(2):265-277. doi: 10.1007/s00192-024-05923-z. Epub 2025 Jan 3.
4
Radiology of fibrosis part III: genitourinary system.纤维化的放射学第三部分：泌尿生殖系统。
J Transl Med. 2024 Jul 3;22(1):616. doi: 10.1186/s12967-024-05333-1.
5
TGF-β inhibitor treatment of H₂O₂-induced cystitis models provides biochemical mechanism for elucidating interstitial cystitis/painful bladder syndrome patients.TGF-β 抑制剂治疗 H₂O₂ 诱导的膀胱炎模型为阐明间质性膀胱炎/膀胱疼痛综合征患者提供了生化机制。
PLoS One. 2023 Nov 6;18(11):e0293983. doi: 10.1371/journal.pone.0293983. eCollection 2023.
6
Intravesical Contrast-Enhanced MRI: A Potential Tool for Bladder Cancer Surveillance and Staging.膀胱内对比增强 MRI：膀胱癌监测和分期的潜在工具。
Curr Oncol. 2023 Apr 30;30(5):4632-4647. doi: 10.3390/curroncol30050350.
7
Molecular Mechanisms and Key Processes in Interstitial, Hemorrhagic and Radiation Cystitis.间质性、出血性和放射性膀胱炎的分子机制及关键过程
Biology (Basel). 2022 Jun 28;11(7):972. doi: 10.3390/biology11070972.
8
Recent Developments in Imaging in BPS/IC.膀胱疼痛综合征/间质性膀胱炎的影像学最新进展
Curr Bladder Dysfunct Rep. 2019 Dec;14(4):301-307. doi: 10.1007/s11884-019-00556-1. Epub 2019 Dec 14.
9
Current Understanding and Future Perspectives of Interstitial Cystitis/Bladder Pain Syndrome.间质性膀胱炎/膀胱疼痛综合征的当前认识与未来展望
Int Neurourol J. 2021 Jun;25(2):99-110. doi: 10.5213/inj.2142084.042. Epub 2021 Jun 30.
10
Peculiarities of the regional dynamics of the prevalence and incidence of cystitis in children.膀胱炎在儿童中流行率和发病率的区域性动态特点。
J Med Life. 2021 Mar-Apr;14(2):210-215. doi: 10.25122/jml-2020-0121.
阿德米多醇+透明质酸钠用于间质性膀胱炎/膀胱疼痛综合征或与慢性尿路上皮炎症相关的病症。一项转化研究。
Pharmacol Res. 2018 Aug;134:16-30. doi: 10.1016/j.phrs.2018.05.013. Epub 2018 May 22.
4
Endoscopic Injection of Low Dose Triamcinolone: A Simple, Minimally Invasive, and Effective Therapy for Interstitial Cystitis With Hunner Lesions.内镜下注射低剂量曲安奈德：一种治疗伴有Hunner溃疡的间质性膀胱炎的简单、微创且有效的疗法。
Urology. 2018 Aug;118:25-29. doi: 10.1016/j.urology.2018.03.037. Epub 2018 May 18.
5
Novel contrast mixture achieves contrast resolution of human bladder wall suitable for T1 mapping: applications in interstitial cystitis and beyond.新型对比剂混合物实现了适用于T1映射的人体膀胱壁对比分辨率：在间质性膀胱炎及其他疾病中的应用。
Int Urol Nephrol. 2018 Mar;50(3):401-409. doi: 10.1007/s11255-018-1794-0. Epub 2018 Feb 1.
6
Differences in Urodynamic Parameters According to the Presence of a Hunner Lesion in Women With Interstitial Cystitis/Bladder Pain Syndrome.间质性膀胱炎/膀胱疼痛综合征女性中，根据是否存在Hunner病变的尿动力学参数差异
Int Neurourol J. 2018 Jan;22(Suppl 1):S55-61. doi: 10.5213/inj.1835044.522. Epub 2018 Jan 31.
7
Development of an interstitial cystitis risk score for bladder permeability.用于膀胱通透性的间质性膀胱炎风险评分的开发。
PLoS One. 2017 Oct 31;12(10):e0185686. doi: 10.1371/journal.pone.0185686. eCollection 2017.
8
Histopathological characteristics of interstitial cystitis/bladder pain syndrome without Hunner lesion.无 Hunner 病变间质性膀胱炎/膀胱疼痛综合征的组织病理学特征。
Histopathology. 2017 Sep;71(3):415-424. doi: 10.1111/his.13235. Epub 2017 Jun 16.
9
Novel contrast mixture improves bladder wall contrast for visualizing bladder injury.新型造影剂混合物可改善膀胱壁造影效果，有助于可视化膀胱损伤。
Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F155-F162. doi: 10.1152/ajprenal.00609.2016. Epub 2017 Mar 29.
10
Characterizing Health Care Utilization, Direct Costs, and Comorbidities Associated with Interstitial Cystitis: A Retrospective Claims Analysis.中文译文： 一项回顾性理赔分析：描述间质性膀胱炎相关的医疗利用、直接成本和合并症。
J Manag Care Spec Pharm. 2017 Apr;23(4):474-482. doi: 10.18553/jmcp.2017.23.4.474.