Roos Juliette, Maenhoudt Cindy, Zilberstein Luca, Mir Fernando, Borges Paulo, Furthner Etienne, Niewiadomska Zuzanna, Nudelmann Nicolas, Fontbonne Alain
CERCA (Centre d'Etudes en Reproduction des Carnivores), Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort Cedex, France.
U955, Equipe 3, Ecole Nationale Vétérinaire d'Alfort, INSERM, UPEC, Créteil, France.
Reprod Domest Anim. 2018 Nov;53 Suppl 3:85-95. doi: 10.1111/rda.13353.
Since most of dystocia end up in caesarean sections (C-sections), the history of any problem during whelping is a good reason to plan in advance a further C-section. Our aim was to confirm that on a large sample and over an extended period of time, mortality in puppies <2 weeks of age was low, born after a planned C-section using aglepristone as a primer. Seventy-four C-sections on 59 different bitches were included. Bitches were monitored during oestrus to estimate the day of ovulation by progesterone assays; 60, 61 or 62 days after ovulation, foetal viability was checked by ultrasonography and progesterone plasma level was measured. None of the bitches was at term (progesterone plasma level >2 ng/ml). An injection of aglepristone was performed in late afternoon to block the effect of progesterone, mimicking its drop at the end of pregnancy. The C-section was conducted the following morning. Twenty-one breeds were represented most of which were bulldogs (26%, 21/74) and Great Danes (16%, 13/74). Four hundred and thirty-five puppies were born. A total of 43/435 puppies died within the first 2 weeks (9.89%). None of the puppies showed any external signs of prematurity. The average number of deaths per litter relative to the date after ovulation was similar (0.5 pups per litter at day 60, 0.7 at day 61, 0.4 at day 62). This study shows that planned C-section after an accurate determination of ovulation and using aglepristone as a primer is a safe procedure for bitches and their offspring. It may be offered to owners if a pregnant bitch is "at risk" of dystocia.
由于大多数难产最终都需要进行剖宫产（C -section），因此分娩过程中出现任何问题的病史都是提前计划再次剖宫产的充分理由。我们的目的是在大样本且较长时间段内证实，使用阿格列司酮作为引产剂进行计划剖宫产出生的 2 周龄以下幼犬死亡率较低。本研究纳入了 59 只不同母犬的 74 例剖宫产。在发情期对母犬进行监测，通过孕酮检测来估计排卵日期；排卵后 60、61 或 62 天，通过超声检查检查胎儿活力并测量血浆孕酮水平。没有一只母犬足月（血浆孕酮水平>2 ng/ml）。在傍晚注射阿格列司酮以阻断孕酮的作用，模拟其在妊娠末期的下降。次日早晨进行剖宫产。涉及 21 个品种，其中大多数是斗牛犬（26%，21/74）和大丹犬（16%，13/74）。共出生 435 只幼犬。共有 43/435 只幼犬在出生后 2 周内死亡（9.89%）。没有一只幼犬表现出任何早产的外部迹象。相对于排卵后的日期，每窝幼犬的平均死亡数相似（排卵后第 60 天每窝 0.5 只幼犬死亡，第 61 天为 0.7 只，第 62 天为 0.4 只）。本研究表明，在准确确定排卵并使用阿格列司酮作为引产剂后进行计划剖宫产，对母犬及其后代来说是一种安全的手术。如果怀孕母犬有难产“风险”，可以向犬主推荐这种方法。
