Kent Stephen J, Flexner Charles
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, 3010, Australia.
Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Health, Central Clinical School, Monash University, Melbourne, Australia.
AIDS Res Ther. 2018 Nov 24;15(1):22. doi: 10.1186/s12981-018-0211-1.
Ageing is the result of biological events that progressively and irreversibly compromise the function of vital organs and eventually result in death. There is a general perception that ageing is accelerated in people living with HIV, with an increasing body of evidence to support this view. With the introduction of effective antiretroviral therapy, the life expectancy of people living with HIV has improved. Since people with HIV are living longer than previously, while also ageing faster than the general population, there is an increase in HIV-positive patients living with age-related comorbidities. This brief overview of ageing and HIV discusses aspects of the complications of HIV infection as they impact the ageing process. How diseases of age affect patients with HIV provides clues to help unravel the interactions between HIV and ageing that ultimately should help clinicians understand the basis of 'normal' ageing and manage ageing HIV-positive patients more effectively.
衰老乃是生物过程的结果，这些过程会逐渐且不可逆地损害重要器官的功能，并最终导致死亡。人们普遍认为，感染艾滋病毒者的衰老进程会加速，且越来越多的证据支持这一观点。随着有效抗逆转录病毒疗法的引入，感染艾滋病毒者的预期寿命有所提高。由于感染艾滋病毒者的寿命比以前更长，同时衰老速度也比普通人群更快，因此感染艾滋病毒且患有与年龄相关合并症的患者有所增加。本关于衰老与艾滋病毒的简要概述探讨了艾滋病毒感染并发症影响衰老过程的各个方面。老年疾病如何影响艾滋病毒感染者，为揭示艾滋病毒与衰老之间的相互作用提供了线索，这最终应有助于临床医生理解“正常”衰老的基础，并更有效地管理老年艾滋病毒感染者。
