脂肪来源干细胞的 3D 生物打印用于器官制造。
3D Bioprinting of Adipose-Derived Stem Cells for Organ Manufacturing.
机构信息
Center of Organ Manufacturing, Department of Tissue Engineering, China Medical University (CMU), Shenyang, People's Republic of China.
Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, Beijing, People's Republic of China.
出版信息
Adv Exp Med Biol. 2018;1078:3-14. doi: 10.1007/978-981-13-0950-2_1.
Organ manufacturing is an attractive high-tech research field which can solve the serious donor shortage problems for allograft organ transplantation, high throughput drug screening, and energy metabolism model establishment. How to integrate heterogeneous cell types along with other biomaterials to form bioartificial organs is one of the kernel issues for organ manufacturing. At present, three-dimensional (3D) bioprinting of adipose-derives stem cell (ADSC) containing hydrogels has shown the most bright futures with respect to overcoming all the difficult problems encountered by tissue engineers over the last several decades. In this chapter, we briefly introduce the 3D ADSC bioprinting technologies for organ manufacturing, especially for the branched vascular network construction.
器官制造是一个极具吸引力的高科技研究领域，可以解决同种异体器官移植的严重供体短缺问题、高通量药物筛选和能量代谢模型建立等问题。如何将异质细胞类型与其他生物材料结合起来形成生物人工器官是器官制造的核心问题之一。目前，含凝胶的脂肪来源干细胞（ADSC）的三维（3D）生物打印在克服组织工程师在过去几十年中遇到的所有难题方面显示出最光明的前景。在本章中，我们简要介绍了用于器官制造的 3D ADSC 生物打印技术，特别是用于分支血管网络构建的技术。
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