接受苯妥英治疗的癫痫患者体内的淋巴细胞毒素。
Lymphocytotoxins in epileptic patients receiving phenytoin.
作者信息
Ooi B S, Kant K S, Hanenson I B, Pesce A J, Pollak V E
出版信息
Clin Exp Immunol. 1977 Oct;30(1):56-61.
The present study was undertaken to determine the prevalence and nature of lymphocytotoxic antibodies in patients receiving phenytoin. Of forty-six sera examined, lymphocytotoxins and antinuclear antibodies were detected in fourteen and eleven samples respectively. Antibodies to double-stranded RNA (poly-A-poly-U) were found in six out of thirty-eight sera studied. A highly significant correlation was found between the presence of lymphocytotoxins and antinuclear antibodies (chi2 = 9.72; P less than 0.01). Lymphocytotoxins were found to be of the IgM class, to have activity against T and B cells, and to be dependent on the presence of Ca and Mg ions for activity. These findings may have pathogenetic importance in the genesis of the altered immune state of patients reveiving phenytoin.
本研究旨在确定接受苯妥英治疗患者中淋巴细胞毒性抗体的患病率及性质。在检测的46份血清中，分别在14份和11份样本中检测到淋巴细胞毒素和抗核抗体。在所研究的38份血清中，有6份发现了针对双链RNA（聚A-聚U）的抗体。发现淋巴细胞毒素和抗核抗体的存在之间存在高度显著的相关性（χ2 = 9.72；P < 0.01）。发现淋巴细胞毒素属于IgM类，对T细胞和B细胞有活性，并且其活性依赖于钙和镁离子的存在。这些发现可能在接受苯妥英治疗患者免疫状态改变的发生机制中具有致病重要性。
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