视网膜光感受器的功能光学相干断层扫描。
Functional optical coherence tomography of retinal photoreceptors.
机构信息
1 Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
2 Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
出版信息
Exp Biol Med (Maywood). 2018 Dec;243(17-18):1256-1264. doi: 10.1177/1535370218816517. Epub 2018 Nov 27.
Abstract
Retinal photoreceptors are the primary target of age-related macular degeneration (AMD) which is the leading cause of severe vision loss and legal blindness. An objective method for functional assessment of photoreceptor physiology can benefit early detection and better treatment evaluation of AMD and other eye diseases that are known to cause photoreceptor dysfunctions. This article summarizes in vitro study of IOS mechanisms and in vivo demonstration of IOS imaging of intact animals. Further development of the functional IOS imaging may provide a revolutionary solution to achieve objective assessment of human photoreceptors.
摘要
视网膜光感受器是年龄相关性黄斑变性 (AMD) 的主要靶标，AMD 是导致严重视力丧失和法定失明的主要原因。一种用于评估光感受器生理学功能的客观方法，可以有助于早期发现 AMD 和其他已知会引起光感受器功能障碍的眼部疾病，并能更好地评估这些疾病的治疗效果。本文总结了 IOS 机制的体外研究和完整动物的 IOS 成像的体内证明。进一步开发功能 IOS 成像可能为实现对人类光感受器的客观评估提供一个革命性的解决方案。
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本文引用的文献
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Functional optical coherence tomography of neurovascular coupling interactions in the retina.
J Biophotonics. 2018 Dec;11(12):e201800089. doi: 10.1002/jbio.201800089. Epub 2018 Jul 27.
2
In vivo super-resolution imaging of transient retinal phototropism evoked by oblique light stimulation.
J Biomed Opt. 2018 May;23(5):1-4. doi: 10.1117/1.JBO.23.5.050502.
3
Stimulus-evoked outer segment changes occur before the hyperpolarization of retinal photoreceptors.
Biomed Opt Express. 2016 Dec 2;8(1):38-47. doi: 10.1364/BOE.8.000038. eCollection 2017 Jan 1.
4
In vivo super-resolution retinal imaging through virtually structured detection.
J Biomed Opt. 2016 Dec 1;21(12):120502. doi: 10.1117/1.JBO.21.12.120502.
5
In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas.
J Biomed Opt. 2016 Sep 1;21(9):96010. doi: 10.1117/1.JBO.21.9.096010.
6
Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers.
Biomed Opt Express. 2016 Jul 29;7(8):3151-62. doi: 10.1364/BOE.7.003151. eCollection 2016 Aug 1.
7
Stimulus-evoked outer segment changes in rod photoreceptors.
J Biomed Opt. 2016 Jun 1;21(6):65006. doi: 10.1117/1.JBO.21.6.065006.
8
Methods and algorithms for optical coherence tomography-based angiography: a review and comparison.
J Biomed Opt. 2015 Oct;20(10):100901. doi: 10.1117/1.JBO.20.10.100901.
9
Intrinsic optical signal imaging of retinal physiology: a review.
J Biomed Opt. 2015 Sep;20(9):090901. doi: 10.1117/1.JBO.20.9.090901.
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