Kim Tae-Hoon, Le David, Son Taeyoon, Yao Xincheng
Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Biomed Opt Express. 2020 Dec 15;12(1):367-379. doi: 10.1364/BOE.413149. eCollection 2021 Jan 1.
Differential artery-vein (AV) analysis is essential for retinal study, disease detection, and treatment assessment. This study is to characterize vascular reflectance profiles and blood flow patterns of retinal artery and vein systems in optical coherence tomography (OCT) and OCT angiography (OCTA), and establish them as robust signatures for objective AV classification. A custom designed OCT was employed for three-dimensional (3D) imaging of mouse retina, and corresponding OCTA was reconstructed. Radially resliced OCT B-scans revealed two, i.e. top and bottom, hyperreflective wall boundaries in retinal arteries, while these wall boundaries were absent in OCT of retinal veins. Additional OCTA analysis consistently displayed a layered speckle distribution in the vein, which may indicate the venous laminar flow. These OCT and OCTA differences offer unique signatures for objective AV classification in OCT and OCTA.
动静脉差异分析对于视网膜研究、疾病检测和治疗评估至关重要。本研究旨在表征光学相干断层扫描（OCT）和 OCT 血管造影（OCTA）中视网膜动脉和静脉系统的血管反射率分布及血流模式，并将其确立为客观动静脉分类的可靠特征。使用定制设计的 OCT 对小鼠视网膜进行三维（3D）成像，并重建相应的 OCTA。径向重新切片的 OCT B 扫描显示视网膜动脉中有两个高反射壁边界，即顶部和底部，而视网膜静脉的 OCT 中不存在这些壁边界。额外的 OCTA 分析始终显示静脉中有分层的散斑分布，这可能表明静脉层流。这些 OCT 和 OCTA 差异为 OCT 和 OCTA 中的客观动静脉分类提供了独特的特征。
