Clark K E, Miodovnik M, Skillman C A, Mimouni F
A.E. Seeds Perinatal Research Center, Cincinnati, Ohio.
Am J Perinatol. 1988 Oct;5(4):312-8. doi: 10.1055/s-2007-999716.
Studies with pregnant sheep are reviewed, which were designed to investigate whether short-term episodes of maternal hyperglycemia or hyperketonemia were detrimental to the fetus, whether ketones can cross the ovine placenta, and whether the combination of maternal hyperglycemia and hyperketonemia would contribute to an increased risk of fetal morbidity. It is concluded that acute increases in maternal ketones appear to be more detrimental to the fetus than acute increases in maternal glucose, as assessed by fetal cardiovascular, metabolic, and blood gas changes.
对妊娠绵羊的研究进行了综述，这些研究旨在调查母体短期高血糖或高酮血症发作是否对胎儿有害，酮类是否能穿过绵羊胎盘，以及母体高血糖和高酮血症的组合是否会增加胎儿发病风险。结论是，通过胎儿心血管、代谢和血气变化评估，母体酮类的急性增加似乎比母体葡萄糖的急性增加对胎儿更有害。
