Sachu Arun, Madhavan Anitha, Vasudevan Anu, Vasudevapanicker Jayalakshmi
Department of Microbiology, Government TD Medical College, Alappuzha, Kerala, India.
Department of Biostatistics, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.
Iran J Microbiol. 2018 Aug;10(4):227-232.
Dengue and Leptospirosis were often discussed separately with rash being more common in dengue and jaundice in leptospirosis. But with increasing reports of co-infection, the situation has become worse. The main objective of this study was to look for the presence of both Dengue and Leptospira IgM antibodies in serum samples of patients, presenting with acute febrile illness. Medical records of the co-infected patients were examined to analyse the clinical features and laboratory findings.
Serum samples of patients presenting with acute febrile illness were screened for the presence of Dengue IgM antibodies and Leptospira antibodies. Clinical features and laboratory parameters of patients with co-infection were compared with patients having dengue alone. Rainfall data was obtained to look for an association between rainfall and Dengue, leptospirosis and co-infected cases.
Co-infection was seen in 33 (3.4%) samples. There was a statistically significant association between clinical features like rashes, bleeding gums and co-infection. There was a statistically significant association between various laboratory parameters like thrombocytopenia and co-infection. There was positive correlation between rainfall and development of dengue, leptospirosis, and co-infection but it was not statistically significant.
The overall prevalence of co-infection was 3.4%. This study re-emphasizes the fact that dengue and leptospirosis are widely prevalent in south India and clinicians should be aware that co-infection with dengue and leptospirosis is not uncommon.
登革热和钩端螺旋体病过去常被分别讨论，皮疹在登革热中更为常见，黄疸在钩端螺旋体病中更为常见。但随着合并感染报告的增多，情况变得更糟。本研究的主要目的是在出现急性发热性疾病的患者血清样本中寻找登革热和钩端螺旋体IgM抗体。检查合并感染患者的病历以分析临床特征和实验室检查结果。
对出现急性发热性疾病的患者血清样本进行登革热IgM抗体和钩端螺旋体抗体筛查。将合并感染患者的临床特征和实验室参数与单纯感染登革热的患者进行比较。获取降雨数据以寻找降雨与登革热、钩端螺旋体病及合并感染病例之间的关联。
在33份（3.4%）样本中发现合并感染。皮疹、牙龈出血等临床特征与合并感染之间存在统计学显著关联。血小板减少等各种实验室参数与合并感染之间存在统计学显著关联。降雨与登革热、钩端螺旋体病及合并感染的发生呈正相关，但无统计学意义。
合并感染的总体患病率为3.4%。本研究再次强调了登革热和钩端螺旋体病在印度南部广泛流行这一事实，临床医生应意识到登革热和钩端螺旋体病合并感染并不罕见。
