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通过碳水化合物酶辅助提取获得的十种斯里兰卡海藻提取物的抗氧化和抗炎功能

Antioxidant and anti-inflammatory functionality of ten Sri Lankan seaweed extracts obtained by carbohydrase assisted extraction.

作者信息

Shanura Fernando I P, Asanka Sanjeewa K K, Samarakoon Kalpa W, Lee Won Woo, Kim Hyun-Soo, Ranasinghe P, Gunasekara U K D S S, Jeon You-Jin

机构信息

1Department of Marine Life Science, Jeju National University, Jeju, 63243 Republic of Korea.

2Industrial Technology Institute (ITI), 363, Bauddhaloka Mawatha, Colombo 7, Sri Lanka.

出版信息

Food Sci Biotechnol. 2018 Jun 1;27(6):1761-1769. doi: 10.1007/s10068-018-0406-1. eCollection 2018 Dec.

DOI:10.1007/s10068-018-0406-1
PMID:30483441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6233398/
Abstract

Enzyme-assisted extraction is a cost-effective, safe, and efficient method to obtain bioactives from plant materials. During this study, 10 different marine algae from Sri Lanka were individually extracted by using five commercial food-grade carbohydrases. The enzymatic and water extracts of the seaweeds were analyzed for their antioxidant and anti-inflammatory activities. The highest DPPH, hydrogen peroxide (HO) and intracellular HO scavenging abilities were observed from the Celluclast extract of (CSp). CSp exerted protective effects against oxidative stress-induced cell death in hydrogen peroxide-induced Chang cells and in model zebrafish. The Celluclast extract of (CCm) showed the strongest anti-inflammatory activity against lipopolysaccharide (LPS)-induced NO production in RAW 264.7 macrophages (IC = 44.47 µg/mL) and in model zebrafish. CCm inhibited the levels of iNOS, COX-2, PGE, and TNF-α in LPS stimulated RAW 264.7 macrophages. Hence, CSp and CCm could be utilized in developing functional ingredients for foods, and cosmeceuticals.

摘要

酶辅助提取是一种从植物材料中获取生物活性成分的经济高效且安全的方法。在本研究中，使用五种商业食品级碳水化合物酶分别对来自斯里兰卡的10种不同海藻进行了提取。对海藻的酶提取物和水提取物进行了抗氧化和抗炎活性分析。在（CSp）的纤维素酶提取物中观察到最高的DPPH、过氧化氢（HO）和细胞内HO清除能力。CSp对过氧化氢诱导的Chang细胞和模型斑马鱼中氧化应激诱导的细胞死亡具有保护作用。（CCm）的纤维素酶提取物对RAW 264.7巨噬细胞（IC = 44.47 μg/mL）和模型斑马鱼中脂多糖（LPS）诱导的NO产生表现出最强的抗炎活性。CCm抑制了LPS刺激的RAW 264.7巨噬细胞中iNOS、COX-2、PGE和TNF-α的水平。因此，CSp和CCm可用于开发食品和药妆品的功能性成分。