Poopirom Chanikarn, Yimcharoen Veeritta, Rirattanapong Praphasri
Department of Pediatric Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
J Int Soc Prev Community Dent. 2025 Feb 26;15(1):34-41. doi: 10.4103/jispcd.jispcd_42_24. eCollection 2025 Jan-Feb.
This study aimed to compare the remineralization effect of a fluoride bioactive glass (FBG) toothpaste with different concentrations of sodium fluoride toothpaste based on the surface microhardness (SMH) in artificial enamel carious lesions of primary teeth.
Fifty sound primary incisors were allocated into five groups ( = 10): Group DI (deionized water); Group FBG (Biomin® F); Group 500 ppmF (Jordan®); Group 1000 ppmF (Kodomo®); and Group 1500 ppmF (Systema®). The teeth were fixed in self-cure acrylic resin blocks, and artificial carious lesions were created by immersing them in a demineralizing solution (D1) for 4 days. The specimens underwent 7-day pH-cycling and were treated with the provided toothpaste twice daily. The SMH was examined at baseline, after artificial caries induction, and after pH-cycling. The data were calculated as the percentage SMH recovery (%SMHR). One-way ANOVA, tests (Tukey HSD or Games-Howell tests), and regression analysis were used to analyze the results with a significance level of 0.05.
The %SMHR of the four groups (different toothpastes) was significantly higher than that of the control group, with all toothpaste groups showing a positive effect on %SMHR ( value < 0.001). The highest %SMHR was observed for 1500 ppmF and FBG, with no significant difference ( value = 0.984). Both had the most significant positive effects on %SMHR, with coefficients of 1.076 and 1.002, respectively.
The remineralization effect of the FBG toothpaste was comparable to that of 1500 ppmF toothpaste and had a greater efficacy than those of 500 and 1000 ppmF based on SMH testing on enamel carious lesions in primary teeth. It offers an effective alternative option for toothpaste with a lower risk of systemic fluoride toxicity, offering a safer, effective option for caries prevention in children.
本研究旨在基于乳牙人工釉质龋损的表面显微硬度（SMH），比较不同浓度氟化钠牙膏与一种氟化物生物活性玻璃（FBG）牙膏的再矿化效果。
将50颗健康的乳切牙分为五组（每组n = 10）：DI组（去离子水）；FBG组（Biomin® F）；500 ppmF组（Jordan®）；1000 ppmF组（Kodomo®）；以及1500 ppmF组（Systema®）。将牙齿固定在自凝丙烯酸树脂块中，通过将其浸泡在脱矿溶液（D1）中4天来制造人工龋损。标本进行7天的pH循环，并每天用提供的牙膏处理两次。在基线、人工龋诱导后和pH循环后检查表面显微硬度。数据以表面显微硬度恢复百分比（%SMHR）计算。采用单因素方差分析、检验（Tukey HSD或Games-Howell检验）和回归分析来分析结果，显著性水平为0.05。
四组（不同牙膏组）的%SMHR显著高于对照组，所有牙膏组对%SMHR均显示出积极作用（P值< 0.001）。1500 ppmF组和FBG组观察到最高的%SMHR，两者无显著差异（P值 = 0.984）。两者对%SMHR均有最显著的积极作用，回归系数分别为1.076和1.002。
基于对乳牙釉质龋损的表面显微硬度测试，FBG牙膏的再矿化效果与1500 ppmF牙膏相当，且比500 ppmF和1000 ppmF牙膏的疗效更佳。它为系统性氟中毒风险较低的牙膏提供了一种有效的替代选择，为儿童龋齿预防提供了更安全、有效的选择。
