Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran.
J Cell Biochem. 2019 Mar;120(3):2749-2755. doi: 10.1002/jcb.27415. Epub 2018 Nov 28.
Gold nanoparticles (GNs) have unique characteristics, for example, stability, biocompatibility, small dimensions, and low toxicity. Several clinical applications have been suggested for GNs, such as diagnosis, imaging, and drug delivery. GNs absorb infrared light, indicating their potential value for imaging. There is growing evidence showing the therapeutic application of GN for drug delivery because of their interaction with the blood-brain barrier and DNA, the latter being associated with their genotoxic effects. GN can also be stimulated to produce high local temperatures, indicating their potential value in photodynamic therapy in the treatment of tumors. The aim of the current review is to summarize the potential applications of GNs in the biomedical field, specifically in neurodegenerative diseases.
金纳米颗粒（GNs）具有独特的特性，例如稳定性、生物相容性、小尺寸和低毒性。已经提出了 GNs 的几种临床应用，例如诊断、成像和药物输送。GNs 吸收红外光，这表明它们在成像方面具有潜在价值。越来越多的证据表明 GN 在药物输送方面的治疗应用具有潜在价值，因为它们与血脑屏障和 DNA 相互作用，后者与它们的遗传毒性作用有关。GN 还可以被刺激产生局部高温，这表明它们在肿瘤光动力治疗中的应用具有潜在价值。本综述的目的是总结 GNs 在生物医学领域的潜在应用，特别是在神经退行性疾病中的应用。
