Jiang Pengfei, Wang Yulin, Zhao Lan, Ji Chenyang, Chen Dongchu, Nie Libo
Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou 412007, China.
School of Material Science and Energy Engineering, Foshan University, Foshan 528000, China.
Nanomaterials (Basel). 2018 Nov 26;8(12):977. doi: 10.3390/nano8120977.
Due to their unique properties, such as good biocompatibility, excellent conductivity, effective catalysis, high density, and high surface-to-volume ratio, gold nanoparticles (AuNPs) are widely used in the field of bioassay. Mainly, AuNPs used in optical biosensors have been described in some reviews. In this review, we highlight recent advances in AuNP-based non-optical bioassays, including piezoelectric biosensor, electrochemical biosensor, and inductively coupled plasma mass spectrometry (ICP-MS) bio-detection. Some representative examples are presented to illustrate the effect of AuNPs in non-optical bioassay and the mechanisms of AuNPs in improving detection performances are described. Finally, the review summarizes the future prospects of AuNPs in non-optical biosensors.
由于其独特的性质，如良好的生物相容性、优异的导电性、有效的催化作用、高密度和高比表面积，金纳米颗粒（AuNPs）在生物检测领域得到了广泛应用。主要地，一些综述中已经描述了用于光学生物传感器的金纳米颗粒。在本综述中，我们重点介绍了基于金纳米颗粒的非光学生物检测的最新进展，包括压电热传感器、电化学生物传感器和电感耦合等离子体质谱（ICP-MS）生物检测。给出了一些代表性实例来说明金纳米颗粒在非光学生物检测中的作用，并描述了金纳米颗粒提高检测性能的机制。最后，本综述总结了金纳米颗粒在非光学生物传感器中的未来前景。
