College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, China.
Nat Commun. 2018 Nov 28;9(1):5044. doi: 10.1038/s41467-018-07197-8.
Photodynamic therapy (PDT) is ineffective against deeply seated metastatic tumors due to poor penetration of the excitation light. Herein, we developed a biomimetic nanoreactor (bio-NR) to achieve synergistic chemiexcited photodynamic-starvation therapy against tumor metastasis. Photosensitizers on the hollow mesoporous silica nanoparticles (HMSNs) are excited by chemical energy in situ of the deep metastatic tumor to generate singlet oxygen (O) for PDT, and glucose oxidase (GOx) catalyzes glucose into hydrogen peroxide (HO). Remarkably, this process not only blocks the nutrient supply for starvation therapy but also provides HO to synergistically enhance PDT. Cancer cell membrane coating endows the nanoparticle with biological properties of homologous adhesion and immune escape. Thus, bio-NRs can effectively convert the glucose into O in metastatic tumors. The excellent therapeutic effects of bio-NRs in vitro and in vivo indicate their great potential for cancer metastasis therapy.
光动力疗法（PDT）由于激发光的穿透深度不佳，对深部转移性肿瘤无效。在此，我们开发了一种仿生纳米反应器（bio-NR），以实现针对肿瘤转移的协同化学激发光动力-饥饿治疗。中空介孔硅纳米粒子（HMSNs）上的光敏剂通过深部转移性肿瘤的原位化学能量被激发，产生用于 PDT 的单线态氧（O），葡萄糖氧化酶（GOx）将葡萄糖催化成过氧化氢（HO）。值得注意的是，该过程不仅阻断了饥饿治疗的营养供应，而且还提供了 HO 以协同增强 PDT。癌细胞膜涂层赋予纳米颗粒同源粘附和免疫逃逸的生物学特性。因此，bio-NRs 可以有效地将葡萄糖转化为转移性肿瘤中的 O。bio-NRs 在体外和体内的优异治疗效果表明它们在癌症转移治疗方面具有巨大的潜力。
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