自噬在结直肠癌中的升级作用。
Upgraded role of autophagy in colorectal carcinomas.
作者信息
Koustas Evangelos, Sarantis Panagiotis, Papavassiliou Athanassios G, Karamouzis Michalis V
机构信息
Division of Molecular Oncology, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
出版信息
World J Gastrointest Oncol. 2018 Nov 15;10(11):367-369. doi: 10.4251/wjgo.v10.i11.367.
Abstract
Autophagy is a basic catabolic process closely associated with degradation of cellular components. The role of autophagy in colorectal cancer (CRC) remains controversial. The mechanism of autophagy has been identified as protecting mechanism against tumorigenesis by isolation of damaged organelles or as cytoprotective provides energy in hypoxic regions of CRC tumors. Mutations in proto-oncogenes, such as and , have been associated with autophagy initiation through signaling pathways of BRAF/MEK/ERK and PI3K/AKT/mTOR. A combination therapy of chemotherapeutic agents and autophagy inhibitors such as hydroxychloroquine or immunotherapy might represent a major step that could be evaluated as a putative novel therapeutic strategy in CRC patients.
摘要
自噬是一种与细胞成分降解密切相关的基本分解代谢过程。自噬在结直肠癌（CRC）中的作用仍存在争议。自噬机制已被确定为通过隔离受损细胞器来对抗肿瘤发生的保护机制，或者在CRC肿瘤的缺氧区域作为提供能量的细胞保护机制。原癌基因的突变，如 和 ，已通过BRAF/MEK/ERK和PI3K/AKT/mTOR信号通路与自噬起始相关。化疗药物与自噬抑制剂（如羟氯喹）或免疫疗法的联合治疗可能是一个重要步骤，可作为CRC患者一种推定的新型治疗策略进行评估。
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本文引用的文献
1
Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy.自噬在癌症中的调控：作用与治疗的现有知识。
Oxid Med Cell Longev. 2018 Jan 31;2018:8023821. doi: 10.1155/2018/8023821. eCollection 2018.
2
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Oncotarget. 2017 Jun 27;8(37):62759-62768. doi: 10.18632/oncotarget.18663. eCollection 2017 Sep 22.
3
Co-targeting of EGFR and autophagy signaling is an emerging treatment strategy in metastatic colorectal cancer.联合靶向 EGFR 和自噬信号是转移性结直肠癌的一种新兴治疗策略。
Cancer Lett. 2017 Jun 28;396:94-102. doi: 10.1016/j.canlet.2017.03.023. Epub 2017 Mar 18.
4
The Autophagy Machinery: A New Player in Chemotactic Cell Migration.自噬机制：趋化性细胞迁移中的新角色
Front Neurosci. 2017 Feb 16;11:78. doi: 10.3389/fnins.2017.00078. eCollection 2017.
5
Cancer Statistics, 2017.《2017 年癌症统计》
CA Cancer J Clin. 2017 Jan;67(1):7-30. doi: 10.3322/caac.21387. Epub 2017 Jan 5.
6
Stress-Induced EGFR Trafficking: Mechanisms, Functions, and Therapeutic Implications.应激诱导的表皮生长因子受体转运：机制、功能及治疗意义
Trends Cell Biol. 2016 May;26(5):352-366. doi: 10.1016/j.tcb.2015.12.006. Epub 2016 Jan 27.
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8
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9
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J Biol Chem. 2010 Feb 19;285(8):5438-49. doi: 10.1074/jbc.M109.046789. Epub 2009 Sep 24.
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