Michopoulou Sofia, O'Shaughnessy Emma, Thomson Katharine, Guy Matthew J
University Hospital Southampton NHS Foundation Trust, Southampton.
Poole Hospital NHS Foundation Trust, Poole.
Nucl Med Commun. 2019 Mar;40(3):270-277. doi: 10.1097/MNM.0000000000000962.
The aim of this study was to evaluate and benchmark the performance characteristics of the General Electric (GE) Discovery Molecular Imaging (MI) Digital Ready (DR) PET/CT.
Performance evaluation against the National Electrical Manufacturers Association (NEMA) 2012 standard was performed on three GE Discovery MI DR PET/CT systems installed across different UK centres. The Discovery MI DR performance was compared with the Siemens Biograph mCT Flow, Phillips Ingenuity TF and GE Discovery 690 fully analogue PET/CT systems. In addition, as the Discovery MI DR is upgradable to the Digital MI with silicon photomultipliers, performance characteristics between analogue and digital were compared with assess potential benefits of a system upgrade.
The average NEMA results across three Discovery MI DR scanners were: sensitivity 7.3 cps/kBq, spatial resolution full-width-half-maximum radial 5.5 mm, tangential 4.5 mm and axial 6 mm at 10 cm from the centre of the field-of-view, peak noise equivalent count rate 142 kcps, scatter fraction 37.1%, contrast recovery coefficients from the International Electrotechnical Commission phantom ranged from 52 to 87% for 10-37-mm diameter spheres.
All three Discovery MI DR systems tested in this study exceeded the manufacturer's NEMA specification, yet variability between scanners was noted. Discovery MI DR showed similar performance to Discovery 690 and Ingenuity TF, but lower sensitivity and spatial resolution than Biograph mCT Flow. The Discovery MI DR showed lower spatial resolution and contrast recovery than the 20-cm field-of-view Digital MI.
本研究旨在评估通用电气（GE）探索者分子成像（MI）数字就绪（DR）PET/CT的性能特征并进行基准测试。
在英国不同中心安装的三台GE探索者MI DR PET/CT系统上，依据美国国家电气制造商协会（NEMA）2012标准进行性能评估。将探索者MI DR的性能与西门子Biograph mCT Flow、飞利浦Ingenuity TF以及GE探索者690全模拟PET/CT系统进行比较。此外，由于探索者MI DR可升级为配备硅光电倍增管的数字MI，因此对模拟和数字之间的性能特征进行了比较，以评估系统升级的潜在益处。
三台探索者MI DR扫描仪的平均NEMA结果为：灵敏度7.3 cps/kBq，在距视野中心10 cm处的空间分辨率，径向半高宽为5.5 mm，切向为4.5 mm，轴向为6 mm，峰值噪声等效计数率142 kcps，散射分数37.1%，对于直径为10 - 37 mm的球体，国际电工委员会体模的对比度恢复系数在52%至87%之间。
本研究中测试的所有三台探索者MI DR系统均超出了制造商的NEMA规格，但各扫描仪之间存在差异。探索者MI DR表现出与探索者690和Ingenuity TF相似的性能，但灵敏度和空间分辨率低于Biograph mCT Flow。探索者MI DR的空间分辨率和对比度恢复低于20 cm视野的数字MI。
